{"id":"W2065366744","doi":"10.1593/neo.06745","title":"Telomere Attrition in Isolated High-Grade Prostatic Intraepithelial Neoplasia and Surrounding Stroma Is Predictive of Prostate Cancer","year":2007,"lang":"en","type":"article","venue":"Neoplasia","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Ontario Institute for Cancer Research; University Health Network; University of Toronto; Hospital for Sick Children; Credit Valley Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Telomere; Intraepithelial neoplasia; Prostate cancer; Hazard ratio; Prostate; Stroma; Chromosome instability; Cancer; Oncology; Biology; Genome instability; Proportional hazards model; Telomerase; High-grade prostatic intraepithelial neoplasia; Pathology; Internal medicine; Medicine; Confidence interval; Genetics; Chromosome; Immunohistochemistry; Gene; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005082924,0.0001748842,0.00020344,0.0005884233,0.0003460437,0.0005076726,0.0003048033,0.0002569746,0.00103008],"category_scores_gemma":[0.002695024,0.0001765158,0.0002029568,0.000552497,0.0002920509,0.0002449641,0.0003420833,0.0005279985,0.0001249733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001190942,"about_ca_system_score_gemma":0.0002000993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001392621,"about_ca_topic_score_gemma":0.001747936,"domain_scores_codex":[0.9997801,0.00006773874,0.00001766643,0.00004624441,0.00005852278,0.00002970393],"domain_scores_gemma":[0.9979685,0.0004632979,0.000942286,0.0001296235,0.000163526,0.0003326825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002279313,0.00001350153,0.9971592,0.00001201656,0.00003625827,0.00008595244,0.00002911651,0.00007831622,0.0006519493,0.00001315476,0.00002365311,0.001668887],"study_design_scores_gemma":[0.000002644614,0.00008574749,0.9982322,0.00000432542,0.00003874053,0.0007222226,0.00006883824,0.00042473,0.0002671275,0.00004648984,0.0001045216,0.000002509763],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986258,0.000864893,0.0001297654,0.00002233905,0.00000448762,0.00000234625,0.00004571321,0.000005837763,0.0002987502],"genre_scores_gemma":[0.9997627,0.000104952,0.00003877042,0.000003541469,0.000006427502,7.882087e-7,0.00003177261,7.8376e-7,0.00005016087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001392621,"threshold_uncertainty_score":0.003445983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01198471942507879,"score_gpt":0.2751108501059603,"score_spread":0.2631261306808815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}