{"id":"W2065366953","doi":"10.1016/j.bmc.2006.10.055","title":"C6-(N,N-butyl-methyl-heptanamide) derivatives of estrone and estradiol as inhibitors of type 1 17β-hydroxysteroid dehydrogenase: Chemical synthesis and biological evaluation","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Estrone; Side chain; Stereochemistry; Steroid; Potency; Chemical synthesis; Biological activity; Structure–activity relationship; Hydroxysteroid dehydrogenase; Enzyme inhibitor; Estrogen; Dehydrogenase; Methyl group; Selectivity; Double bond; IC50; Enzyme; In vitro; Biochemistry; Hormone; Alkyl; Internal medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002196401,0.0002118456,0.0002190935,0.0002243047,0.0001517491,0.0001496703,0.0003285053,0.0001931437,0.001792313],"category_scores_gemma":[0.0001157575,0.0001351991,0.0001273251,0.0001890817,0.000170996,0.0001979678,0.0001377947,0.0003031794,0.0004588871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002049354,"about_ca_system_score_gemma":0.0003016588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008779964,"about_ca_topic_score_gemma":0.001779105,"domain_scores_codex":[0.9999231,0.00001431831,0.000005019426,0.000007731924,0.00002376992,0.00002611163],"domain_scores_gemma":[0.9999527,0.000008987162,0.000008343828,0.000004803783,0.000007973415,0.00001720311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001486149,0.0004041162,0.0002695424,0.0001584898,0.00001605166,0.0002542604,0.00005735715,0.001386635,0.9729056,0.001892578,0.0003831233,0.02078619],"study_design_scores_gemma":[0.000238162,0.002404674,0.001421622,0.000009037035,0.00002397438,0.0002977564,0.00002183727,0.0010472,0.9844338,0.0001353936,0.009950913,0.00001569405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9632204,0.01368776,0.00573782,0.0002070664,0.0001326988,0.0002107678,0.000525856,0.0001118193,0.01616582],"genre_scores_gemma":[0.9761844,0.009114423,0.003498353,0.00009262152,0.00003313378,0.00008169184,0.0005449531,0.00001681468,0.01043361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001792313,"threshold_uncertainty_score":0.00599587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007475095664098047,"score_gpt":0.2355071819750306,"score_spread":0.2280320863109326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}