{"id":"W2065390851","doi":"10.1038/clpt.2010.355","title":"A Fresh Look at the Mechanism of Isoniazid-Induced Hepatotoxicity","year":2011,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":191,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Idiosyncrasy; Isoniazid; Metabolite; Clinical pharmacology; Mechanism (biology); Pharmacology; Medicine; Internal medicine; Tuberculosis; Pathology; Economics; Epistemology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006393492,0.001056615,0.001752741,0.002145527,0.0003324809,0.001198473,0.001176871,0.001556257,0.00588788],"category_scores_gemma":[0.0004750576,0.0002928969,0.0005092286,0.001541839,0.0006933243,0.003453176,0.0005889814,0.00277207,0.004062438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000732457,"about_ca_system_score_gemma":0.0008155218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009505213,"about_ca_topic_score_gemma":0.00180108,"domain_scores_codex":[0.9998577,0.00002181212,0.00002151525,0.00002802152,0.00005576366,0.00001507922],"domain_scores_gemma":[0.9997273,0.0001038905,0.00002861446,0.0000132943,0.00009675679,0.00003010934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001027761,0.0001800006,0.0001968457,0.01082001,0.00005777366,0.0006904152,0.00007690167,0.0004450144,0.00588949,0.006084807,0.04904253,0.9264135],"study_design_scores_gemma":[0.00002588554,0.0002371155,0.00122572,0.003179065,0.00006598949,0.00306193,0.00009773433,0.000142873,0.001159208,0.005310089,0.9854646,0.00002962885],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001253145,0.9970535,0.000180791,0.001031401,0.0004556802,0.000003025456,0.00001547516,0.00001135587,0.001123516],"genre_scores_gemma":[0.000629543,0.9969363,0.0001832784,0.0005683172,0.0006351708,0.000003831854,0.00002118753,0.000001555508,0.001020887],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00588788,"threshold_uncertainty_score":0.01969689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5197160465884401,"score_gpt":0.5517765724236009,"score_spread":0.03206052583516084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}