{"id":"W2065463464","doi":"10.1006/dbio.2002.0568","title":"Developmental Changes in Notch1 and Numb Expression Mediated by Local Cell–Cell Interactions Underlie Progressively Increasing Delta Sensitivity in Neural Crest Stem Cells","year":2002,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Robarts Clinical Trials","funders":"National Science Council","keywords":"Neural crest; Biology; NUMB; Notch signaling pathway; Cell biology; Stem cell; Neural stem cell; Cell fate determination; Cell; Signal transduction; Genetics; Embryo; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002069887,0.0002230343,0.000384659,0.0005432912,0.000221003,0.0007938237,0.0004223955,0.0002930594,0.0009675822],"category_scores_gemma":[0.0003515748,0.0003939076,0.0002016057,0.000300339,0.0004275395,0.0005287434,0.0006267524,0.0008543652,0.0003247351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004911623,"about_ca_system_score_gemma":0.0002160141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001209493,"about_ca_topic_score_gemma":0.002513109,"domain_scores_codex":[0.9998003,0.00002071072,0.00002597892,0.00004074666,0.00006417745,0.00004821341],"domain_scores_gemma":[0.9996198,0.00008212138,0.00007405129,0.00005719355,0.0000585565,0.0001082788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006265755,0.000004018832,0.0009061681,0.00001248258,0.000002484353,0.00003986925,0.00003111304,0.00004204712,0.9978999,0.000133616,0.000007570274,0.0008579505],"study_design_scores_gemma":[0.000007233207,0.000061144,0.0614218,0.000006147378,0.00001470521,0.0002857382,0.0001201167,0.0007339197,0.9367089,0.0001271105,0.0005068587,0.000006164009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996322,0.0008265102,0.001983611,0.0000229182,0.000003905246,0.000007263802,0.0001403724,0.00005371371,0.0006396736],"genre_scores_gemma":[0.9967296,0.0005989127,0.001278461,0.00002678387,0.000003597273,0.00001395648,0.000218237,0.00002734546,0.001103083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001209493,"threshold_uncertainty_score":0.003563583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01261102229416972,"score_gpt":0.225656878027862,"score_spread":0.2130458557336923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}