{"id":"W2065470578","doi":"10.1002/gepi.21872","title":"Pathway‐Based Association Study of Multiple Candidate Genes and Multiple Traits Using Structural Equation Models","year":2014,"lang":"en","type":"article","venue":"Genetic Epidemiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Institut National de Santé Publique du Québec; McGill University Health Centre; Douglas Mental Health University Institute; McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Structural equation modeling; Genetic association; Univariate; Candidate gene; Association test; Biology; Genetics; Gene; Association (psychology); Genome-wide association study; Phenotype; Genetic model; Quantitative trait locus; Computational biology; Genotype; Statistics; Multivariate statistics; Psychology; Mathematics; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001843292,0.0002559053,0.0006401569,0.00009585852,0.0001672632,0.000006048645,0.000173457,0.0004070429,0.000006411898],"category_scores_gemma":[0.003904089,0.000244687,0.0001001687,0.0001005879,0.00008176885,0.000005955287,0.0001068776,0.0001178979,0.000001336343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005319661,"about_ca_system_score_gemma":0.00008723474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008537112,"about_ca_topic_score_gemma":0.00092695,"domain_scores_codex":[0.99616,0.001726428,0.000884107,0.0006075662,0.0001220761,0.0004997751],"domain_scores_gemma":[0.9975873,0.0009878927,0.0007633811,0.0003437023,0.0002005023,0.0001172391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00004311843,0.00005558006,0.7644587,0.00001360625,0.00008229083,2.000956e-7,0.0001015591,0.1906907,0.03972808,0.00003136877,0.00004195444,0.004752921],"study_design_scores_gemma":[0.001489587,0.0005844258,0.4409468,0.000005097451,0.00005621891,0.000003106738,0.0001148005,0.5538018,0.001330628,0.001337456,0.000129556,0.0002005475],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8989198,0.0006310226,0.09965493,0.0001221351,0.0001674552,0.0004283933,0.0000370036,0.00001316623,0.00002607693],"genre_scores_gemma":[0.9687471,0.00006634709,0.03049552,0.000300213,0.0001947544,0.0000273273,0.0001110372,0.00002741511,0.00003023543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3631111,"threshold_uncertainty_score":0.9978044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05317984651308058,"score_gpt":0.2954521495441471,"score_spread":0.2422723030310665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}