{"id":"W2065470578","doi":"10.1002/gepi.21872","title":"Pathway‐Based Association Study of Multiple Candidate Genes and Multiple Traits Using Structural Equation Models","year":2014,"lang":"en","type":"article","venue":"Genetic Epidemiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Institut National de Santé Publique du Québec; McGill University Health Centre; Douglas Mental Health University Institute; McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Structural equation modeling; Genetic association; Univariate; Candidate gene; Association test; Biology; Genetics; Gene; Association (psychology); Genome-wide association study; Phenotype; Genetic model; Quantitative trait locus; Computational biology; Genotype; Statistics; Multivariate statistics; Psychology; Mathematics; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007662375,0.0009473726,0.001409505,0.002319995,0.000580358,0.001142321,0.001549924,0.0008856906,0.003177571],"category_scores_gemma":[0.01535392,0.0005491865,0.001894494,0.002600579,0.0008381503,0.001079586,0.001319087,0.001340776,0.0002196285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001243551,"about_ca_system_score_gemma":0.003203433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0533151,"about_ca_topic_score_gemma":0.04663089,"domain_scores_codex":[0.9959685,0.003370252,0.00006982988,0.0003329263,0.0001458731,0.0001126066],"domain_scores_gemma":[0.9876158,0.01091554,0.0005779706,0.0003584452,0.0003612685,0.0001709444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.0004092648,0.0002984953,0.1165924,0.0001988246,0.003067394,0.0005307874,0.0004816995,0.7781454,0.0008006995,0.05608549,0.001223153,0.04216636],"study_design_scores_gemma":[0.00008077906,0.00007825822,0.006400106,0.00001609525,0.000205723,0.00004820991,0.00005256394,0.9707589,0.00008092618,0.02184649,0.0004139599,0.00001793939],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4606845,0.001029851,0.5323013,0.001814954,0.00008130406,0.0003328107,0.001689026,0.0005971921,0.001468988],"genre_scores_gemma":[0.8802848,0.00075524,0.1159518,0.0001025877,0.00003859979,0.0003323327,0.0006864974,0.00004439192,0.001803629],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0533151,"threshold_uncertainty_score":0.1060095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05317984651308058,"score_gpt":0.2954521495441471,"score_spread":0.2422723030310665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}