{"id":"W2065471096","doi":"10.2174/092986711797535173","title":"1,4-Dihydropyridine Scaffold in Medicinal Chemistry, The Story so Far And Perspectives (Part 1): Action in Ion Channels and GPCRs","year":2011,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"DHPS; Ion channel; Scaffold; Dihydropyridine; Chemistry; Calcium channel; Voltage-dependent calcium channel; G protein-coupled receptor; Receptor; Ligand (biochemistry); Scaffold protein; Biophysics; Drug discovery; Calcium; Ligand-gated ion channel; Signal transduction; Biochemistry; Biology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002269949,0.0003737637,0.0004725095,0.0006169084,0.0002268233,0.0005086707,0.0003485411,0.0004915253,0.00376689],"category_scores_gemma":[0.0001590027,0.0002004921,0.0001597219,0.0008544172,0.0003733989,0.001270525,0.0003311214,0.0009178786,0.002389146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005426213,"about_ca_system_score_gemma":0.0004475014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004708771,"about_ca_topic_score_gemma":0.001032924,"domain_scores_codex":[0.9999471,0.000009257998,0.000005933719,0.00001256474,0.00001664558,0.000008483197],"domain_scores_gemma":[0.9999492,0.00001771727,0.000009650255,0.000002843132,0.00001334009,0.000007217307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001279236,0.0001699878,0.0001558112,0.01227728,0.00003449071,0.0005157225,0.0001792895,0.001106951,0.03768151,0.01937417,0.02893426,0.8994427],"study_design_scores_gemma":[0.0000226557,0.0002351245,0.0005887223,0.0006876527,0.00002633871,0.001083786,0.00006961749,0.0002239723,0.0053563,0.003752221,0.9879368,0.00001675204],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001371275,0.9930112,0.0004372483,0.0005989602,0.0003096533,0.000008040937,0.00003405353,0.00002046114,0.004209089],"genre_scores_gemma":[0.00688157,0.9878801,0.0006792623,0.0004492218,0.0003066644,0.000008637498,0.00003808631,0.000003382987,0.003753247],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00376689,"threshold_uncertainty_score":0.01260149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09007244671368171,"score_gpt":0.3216648852416772,"score_spread":0.2315924385279955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}