{"id":"W2065498651","doi":"10.1124/jpet.113.203315","title":"Modulation of the Antidepressant-Like Effects of Sustained Administration of Carisbamate and Lamotrigine on Monoaminergic Systems: Electrophysiological Studies in the Rat Brain","year":2013,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Lamotrigine; Pharmacology; Monoaminergic; Chemistry; Antidepressant; Dorsal raphe nucleus; Serotonergic; Neuroscience; Serotonin; Psychology; Hippocampus; Medicine; Receptor; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001577914,0.0003323799,0.0003912579,0.0001848038,0.000150131,0.0002566247,0.0003588611,0.0005403421,0.002005036],"category_scores_gemma":[0.0002263864,0.0002058949,0.0003426444,0.0001940436,0.0003070684,0.0004510203,0.0001236673,0.0007180588,0.0002440983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002642978,"about_ca_system_score_gemma":0.0003170786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001494093,"about_ca_topic_score_gemma":0.003473931,"domain_scores_codex":[0.9999245,0.00001484759,0.000006754437,0.00001143006,0.0000104272,0.0000320113],"domain_scores_gemma":[0.9998541,0.00003320168,0.00003229598,0.00001817573,0.0000232767,0.00003899985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003390692,0.0001197366,0.0002726968,0.000095209,0.0000477636,0.00009907481,0.00003948571,0.00003517064,0.9912794,0.0001371445,0.00005577972,0.004427873],"study_design_scores_gemma":[0.000768755,0.01045926,0.04950045,0.00004136167,0.0003086983,0.0006683634,0.0002407821,0.001386749,0.9351655,0.000250319,0.001189624,0.00002024725],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960299,0.002206172,0.0006778106,0.00007997105,0.00002263205,0.00002812816,0.0002171657,0.00001881621,0.0007193857],"genre_scores_gemma":[0.9955396,0.002234249,0.0007438912,0.00005576939,0.00002619721,0.00006508106,0.0002036655,0.000006447574,0.001125119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002005036,"threshold_uncertainty_score":0.006707549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.025041951560154,"score_gpt":0.3514148818006647,"score_spread":0.3263729302405107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}