{"id":"W2065498897","doi":"10.1038/nature09165","title":"Conserved role of intragenic DNA methylation in regulating alternative promoters","year":2010,"lang":"en","type":"article","venue":"Nature","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1765,"is_retracted":false,"has_abstract":false,"ca_institutions":"Douglas Mental Health University Institute; University of British Columbia; BC Cancer Agency","funders":"National Institute of Environmental Health Sciences; Howard Hughes Medical Institute","keywords":"Promoter; DNA methylation; Biology; Epigenetics of physical exercise; CpG site; Methylation; Genetics; Gene; Differentially methylated regions; Molecular biology; RNA-Directed DNA Methylation; Transcription (linguistics); Regulation of gene expression; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002281564,0.0002904963,0.0002609307,0.0003325301,0.000308014,0.0006040878,0.0005558703,0.0004610151,0.001558632],"category_scores_gemma":[0.0002325535,0.0002780524,0.0002592003,0.0001951396,0.0003919112,0.0005607257,0.0005104758,0.0009372556,0.0006875205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003013176,"about_ca_system_score_gemma":0.0001915337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003935388,"about_ca_topic_score_gemma":0.0007252863,"domain_scores_codex":[0.9998339,0.00002325538,0.000006687388,0.00006063385,0.00004136738,0.0000340508],"domain_scores_gemma":[0.9997877,0.00003708727,0.00003243282,0.0000690641,0.00003202047,0.00004161158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001045492,0.00001225367,0.0005931592,0.00002205992,0.000006170998,0.0001264759,0.0000363326,0.0001383657,0.9901813,0.003053632,0.00006485899,0.005660891],"study_design_scores_gemma":[0.00001799081,0.0001340346,0.01168744,0.000008708501,0.00002125268,0.0008488738,0.00005092373,0.002478309,0.9766114,0.00274062,0.005386066,0.00001424018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9102827,0.005907362,0.06934392,0.0004236163,0.000169753,0.00002929009,0.0002952315,0.0005525633,0.0129957],"genre_scores_gemma":[0.9838439,0.0008260267,0.009603585,0.0001032027,0.00003835699,0.00001468628,0.0002609878,0.00008588794,0.005223436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001558632,"threshold_uncertainty_score":0.005214155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004945052448378222,"score_gpt":0.2580452265444578,"score_spread":0.2531001740960796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}