{"id":"W2065520618","doi":"10.1038/emboj.2009.196","title":"Novel roles for A‐type lamins in telomere biology and the DNA damage response pathway","year":2009,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":251,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"CancerCare Manitoba Foundation","keywords":"Lamin; Biology; LMNA; Genome instability; Telomere; Nuclear lamina; Heterochromatin; Cell biology; Premature aging; DNA repair; DNA damage; Genetics; Progeria; Intermediate filament; Mutation; Chromatin; Nuclear protein; Gene; DNA; Cytoskeleton; Cell; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004360637,0.0003106384,0.0002481603,0.0004544506,0.0006468484,0.001565733,0.0004351344,0.001103739,0.001905656],"category_scores_gemma":[0.0003203685,0.0002238119,0.0003652463,0.0002057136,0.000581986,0.001300648,0.0004046641,0.000792339,0.0004760414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005677,"about_ca_system_score_gemma":0.0003464705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002666067,"about_ca_topic_score_gemma":0.0004892176,"domain_scores_codex":[0.9998819,0.00002825545,0.000009823238,0.00002442635,0.00002492306,0.00003072889],"domain_scores_gemma":[0.9997661,0.0000468311,0.0000525085,0.00003610361,0.00003092216,0.0000675473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001016288,0.0001020276,0.001108279,0.000135961,0.00004768996,0.00119909,0.0001152888,0.0003303963,0.9717201,0.01083413,0.0004672681,0.01292347],"study_design_scores_gemma":[0.0006789263,0.001857053,0.0542904,0.0001595605,0.0002972595,0.01781773,0.001226701,0.01060821,0.7969037,0.04161252,0.07437194,0.0001760803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9380119,0.04000049,0.007720306,0.002752484,0.0002043003,0.00001596591,0.0001946765,0.0001994463,0.01090036],"genre_scores_gemma":[0.9841632,0.006778706,0.003670045,0.0003151806,0.0001395697,0.0000139021,0.0001663724,0.00001491696,0.004738127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001905656,"threshold_uncertainty_score":0.006375015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03270001612575184,"score_gpt":0.3197327550283249,"score_spread":0.287032738902573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}