{"id":"W206556033","doi":"10.1007/978-1-60327-569-9_7","title":"Electrochemical DNA Biosensors: Protocols for Intercalator-Based Detection of Hybridization in Solution and at the Surface","year":2009,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Biosensor; DNA; Nanotechnology; Nucleic acid; Intercalation (chemistry); DNA–DNA hybridization; Computational biology; Electrochemistry; Hybridization probe; Chemistry; Materials science; Combinatorial chemistry; Computer science; Biology; Biochemistry; Electrode; Inorganic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001707765,0.00193867,0.001689884,0.00231818,0.0008078553,0.001457317,0.003725983,0.002483244,0.003234853],"category_scores_gemma":[0.001512004,0.001560712,0.0007898574,0.002121977,0.001216904,0.001678142,0.001474302,0.003356017,0.004953307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001095345,"about_ca_system_score_gemma":0.0008754035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006819714,"about_ca_topic_score_gemma":0.001183708,"domain_scores_codex":[0.9973086,0.0003584195,0.0001282975,0.0003435098,0.001723473,0.0001376882],"domain_scores_gemma":[0.9995835,0.0001131364,0.00005749909,0.00005376624,0.0001525867,0.00003933975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009144875,0.0001322085,0.0002530258,0.002588313,0.00008741768,0.0002326665,0.0003792325,0.0007367322,0.8245768,0.01678845,0.01489045,0.1392433],"study_design_scores_gemma":[0.00004209674,0.0001759394,0.0004777837,0.0001654288,0.00004175918,0.002014842,0.00008101523,0.002621689,0.7094325,0.00466062,0.2801705,0.0001157515],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"protocol","genre_scores_codex":[0.0112063,0.1061152,0.8561953,0.001774843,0.002280022,0.001414505,0.001344403,0.004764067,0.01490533],"genre_scores_gemma":[0.05393146,0.09365527,0.7973894,0.002158703,0.0006258637,0.002517154,0.002763318,0.0005350015,0.04642386],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.003725983,"threshold_uncertainty_score":0.0108217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01544481105340305,"score_gpt":0.3837076770750583,"score_spread":0.3682628660216553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}