{"id":"W2065565886","doi":"10.1152/ajpendo.00328.2011","title":"Insulin detemir enhances proglucagon gene expression in the intestinal L cells via stimulating β-catenin and CREB activities","year":2012,"lang":"en","type":"article","venue":"American Journal of Physiology-Endocrinology and Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Novo Nordisk","keywords":"Proglucagon; CREB; Insulin; Insulin detemir; Cell biology; Gene; Endocrinology; Gene expression; Chemistry; Internal medicine; Biology; Glucagon-like peptide-1; Genetics; Diabetes mellitus; Transcription factor; Medicine; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000114076,0.000340549,0.0002259849,0.0002479304,0.00009587569,0.0002427274,0.0001356616,0.0001634381,0.001783688],"category_scores_gemma":[0.0000612224,0.0001483103,0.0003207423,0.0001169675,0.0002164336,0.0002141128,0.0001536229,0.0006128618,0.0003314815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001393942,"about_ca_system_score_gemma":0.0001294314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002884359,"about_ca_topic_score_gemma":0.0004537308,"domain_scores_codex":[0.999916,0.00001151636,0.000009527419,0.00002223123,0.00001729232,0.00002344061],"domain_scores_gemma":[0.9999335,0.00001098568,0.00001925558,0.000006326267,0.00000472937,0.00002516928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002531795,0.00005180077,0.000120572,0.00003445282,0.000002552394,0.00002580341,0.00001346178,0.00001207561,0.9985414,0.0000213481,0.00001900556,0.0009044158],"study_design_scores_gemma":[0.00006271856,0.001119716,0.006205766,0.000009266562,0.00001898619,0.0001633357,0.00007306122,0.000483353,0.989858,0.00002751852,0.001973005,0.000005141653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957533,0.001186207,0.001197712,0.000103688,0.00002787777,0.00001735612,0.0002206147,0.00008966518,0.001403539],"genre_scores_gemma":[0.9933615,0.001120434,0.00181812,0.0001017176,0.00001742106,0.00004374219,0.0005379748,0.00001676241,0.002982355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001783688,"threshold_uncertainty_score":0.005967081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01386055825187568,"score_gpt":0.267228597043017,"score_spread":0.2533680387911413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}