{"id":"W2065577413","doi":"10.1371/journal.pone.0028757","title":"Polyvalent DNA Vaccines Expressing HA Antigens of H5N1 Influenza Viruses with an Optimized Leader Sequence Elicit Cross-Protective Antibody Responses","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Government of Jiangsu Province; Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China","keywords":"Influenza A virus subtype H5N1; Virology; Biology; Hemagglutinin (influenza); Antigenic drift; Clade; Antigen; H5N1 genetic structure; Antibody; Antigenic shift; Influenza A virus; Virus; Microbiology; Gene; Phylogenetics; Genetics; Medicine; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002535105,0.0006453217,0.0002647823,0.0003414166,0.00008957763,0.0002824557,0.0002591432,0.0004283564,0.0008555712],"category_scores_gemma":[0.0002081514,0.0001794299,0.0002150173,0.0001879151,0.0002275626,0.0002492344,0.0002310603,0.0005590463,0.0003493287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002940597,"about_ca_system_score_gemma":0.0001611779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002868147,"about_ca_topic_score_gemma":0.000556494,"domain_scores_codex":[0.9997841,0.00003743423,0.00002003183,0.00005805225,0.00005749768,0.0000430162],"domain_scores_gemma":[0.9998734,0.00002899603,0.00004328281,0.00001204746,0.00002102065,0.00002126138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008812115,0.0001103108,0.0001324072,0.00004218384,0.00000717573,0.0000161237,0.000009708549,0.0001975772,0.9971486,0.00005590605,0.00002310492,0.002168881],"study_design_scores_gemma":[0.0000732027,0.002118499,0.001674681,0.0000105518,0.00003827992,0.0001211321,0.00001599114,0.001661178,0.9928111,0.00004647348,0.001423032,0.000005822872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904912,0.0007296767,0.007619615,0.00005420346,0.00004817968,0.00007949223,0.0001129752,0.00004380196,0.0008208159],"genre_scores_gemma":[0.9896283,0.0005875463,0.007385474,0.0001100236,0.00001993061,0.00005338139,0.000409102,0.00001735367,0.001788875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008555712,"threshold_uncertainty_score":0.002862155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3905822232680781,"score_gpt":0.431253524221844,"score_spread":0.04067130095376592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}