{"id":"W2065619933","doi":"10.1042/bj20061319","title":"Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity","year":2007,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Canadian Institutes of Health Research; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"NAD+ kinase; Biochemistry; Dehydrogenase; Enzyme; Biology; Hydroxysteroid Dehydrogenases; Reductase; Steroid; Active site; Cytosol; Isozyme; Chemistry; Molecular biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008666295,0.0002734931,0.000182427,0.0001205257,0.00007926961,0.0002411261,0.0001443247,0.0001821737,0.001950157],"category_scores_gemma":[0.0001255397,0.00007166762,0.0003122995,0.0001309756,0.000176906,0.0001090288,0.0000874577,0.0002264355,0.000783851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002666929,"about_ca_system_score_gemma":0.0002142742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001321253,"about_ca_topic_score_gemma":0.001173084,"domain_scores_codex":[0.999954,0.000005700355,0.000002986529,0.00001566777,0.00001146443,0.00001022525],"domain_scores_gemma":[0.9999144,0.00001506369,0.00001796143,0.00001072603,0.0000102194,0.00003156766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006911953,0.00003216149,0.003351704,0.0001085294,0.0000215949,0.0009106336,0.00004687196,0.000162854,0.9863018,0.0003482658,0.0002173634,0.007807022],"study_design_scores_gemma":[0.0001285891,0.001071769,0.07805345,0.00003040541,0.0001025815,0.009889476,0.0002915112,0.003501307,0.8546248,0.0004856257,0.05178671,0.00003381639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991869,0.002730485,0.002811388,0.000247104,0.00005439965,0.0000157915,0.001010375,0.00005337643,0.001208115],"genre_scores_gemma":[0.9833108,0.002164753,0.004524345,0.000112663,0.00005894534,0.00001061285,0.005209743,0.00002213351,0.004585991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001950157,"threshold_uncertainty_score":0.006523907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02364435504221108,"score_gpt":0.2789304883923667,"score_spread":0.2552861333501557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}