{"id":"W2065619933","doi":"10.1042/bj20061319","title":"Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity","year":2007,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Canadian Institutes of Health Research; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"NAD+ kinase; Biochemistry; Dehydrogenase; Enzyme; Biology; Hydroxysteroid Dehydrogenases; Reductase; Steroid; Active site; Cytosol; Isozyme; Chemistry; Molecular biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002279791,0.0001613255,0.0003307721,0.0001229413,0.00008784312,0.00002064361,0.0000580895,0.0001554111,0.00003885007],"category_scores_gemma":[0.00005900601,0.0001143754,0.00007014255,0.0001501888,0.0001554504,0.00009227669,0.00003446878,0.0002775509,0.000001188903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006318718,"about_ca_system_score_gemma":0.00005757352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004111962,"about_ca_topic_score_gemma":7.385084e-7,"domain_scores_codex":[0.9988331,0.00001645067,0.0003386493,0.0001952841,0.0003776297,0.0002389312],"domain_scores_gemma":[0.9990292,0.00002745244,0.0002194544,0.0001326894,0.0002079612,0.0003832915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000812247,0.0001048744,0.00387916,0.00003134398,0.00004649122,0.00003957866,0.00006116146,4.976328e-8,0.9937583,0.00002946303,0.00003351554,0.001203809],"study_design_scores_gemma":[0.001770671,0.0002756722,0.1824507,0.0001272217,0.00006433853,0.002702727,0.00001391216,0.00009209185,0.8123243,0.00001504755,0.00005373282,0.0001096466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985437,0.0001187651,0.0008168871,0.0002877922,0.00002523759,0.000147267,0.000009252464,0.00001658047,0.00003451238],"genre_scores_gemma":[0.9986849,0.00001597394,0.0007400564,0.0001692278,0.000293951,8.384662e-7,0.0000353668,0.0000191721,0.00004055865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.181434,"threshold_uncertainty_score":0.4664094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02364435504221108,"score_gpt":0.2789304883923667,"score_spread":0.2552861333501557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}