{"id":"W2065623515","doi":"10.1210/me.2011-1245","title":"Biasing the Prostaglandin F2α Receptor Responses toward EGFR-Dependent Transactivation of MAPK","year":2012,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Medical University of South Carolina","keywords":"Transactivation; Biology; Cell biology; MAPK/ERK pathway; Receptor; Signal transduction; Kinase; Prostaglandin E2 receptor; Endocrinology; Biochemistry; Transcription factor; Agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002658446,0.0001776022,0.0001898644,0.00007386317,0.00008378506,0.00001371475,0.0002250343,0.0001393089,0.0001239464],"category_scores_gemma":[0.0001099396,0.0001377259,0.0001304596,0.0000943639,0.000093173,0.000007752552,0.00007189887,0.0001395499,0.00001180899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002123577,"about_ca_system_score_gemma":0.00004323708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002710854,"about_ca_topic_score_gemma":0.000002501621,"domain_scores_codex":[0.9985315,0.0002793529,0.0002798858,0.0002615462,0.0001764991,0.0004712193],"domain_scores_gemma":[0.9993504,0.00003207287,0.0001298361,0.0003479541,0.00007334627,0.00006641968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002272336,0.00006139668,0.0007418017,0.00001374548,0.0000755933,0.000003253675,0.0002593626,0.00003730946,0.9925955,0.001450754,0.0000991421,0.004434917],"study_design_scores_gemma":[0.000442763,0.0002397431,0.0004381844,0.000009879755,0.00002550338,0.00005318878,0.000301383,0.000007966733,0.9875879,0.0001201757,0.01061746,0.0001558434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9600574,0.001953564,0.0366133,0.0003921386,0.0003888308,0.0002855981,0.00001872809,0.00001751179,0.0002728818],"genre_scores_gemma":[0.9976739,0.0002688438,0.001360181,0.0002298096,0.0001465886,0.00004408895,0.00005763377,0.00003168618,0.0001873113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03761641,"threshold_uncertainty_score":0.5616298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02215929924194963,"score_gpt":0.2644557821316848,"score_spread":0.2422964828897352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}