{"id":"W2065627587","doi":"10.1016/j.chom.2008.03.008","title":"Mycobacterium tuberculosis Virulence Is Mediated by PtpA Dephosphorylation of Human Vacuolar Protein Sorting 33B","year":2008,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":323,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"British Columbia Centre for Disease Control","keywords":"Biology; Vacuolar protein sorting; Protein tyrosine phosphatase; Cell biology; Phagosome; Mycobacterium tuberculosis; Phosphorylation; Lysosome; Immunoprecipitation; Tyrosine phosphorylation; Intracellular; Endosome; Gene; Tuberculosis; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001897784,0.0002645878,0.0001928899,0.0002553064,0.0002582897,0.0004122466,0.0001747427,0.0003161957,0.00197206],"category_scores_gemma":[0.0003441715,0.0002922152,0.0002941169,0.0001269493,0.0002399073,0.000182897,0.0004723332,0.0004848184,0.0009191621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004250809,"about_ca_system_score_gemma":0.0002512103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009074282,"about_ca_topic_score_gemma":0.0008298896,"domain_scores_codex":[0.9997992,0.00004260129,0.0000135781,0.00003606984,0.0000426867,0.00006590608],"domain_scores_gemma":[0.9998337,0.00002846046,0.00006300263,0.0000218548,0.00001676559,0.00003611907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003750626,0.00002995269,0.0009215529,0.00003111113,0.000006134376,0.0001488165,0.0000143342,0.0000573562,0.9966964,0.0002560412,0.0001383794,0.001324938],"study_design_scores_gemma":[0.0001218904,0.0003881913,0.1022062,0.00002631267,0.00002629183,0.002717349,0.0001160932,0.003628528,0.8854491,0.0006753691,0.004625352,0.00001926431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945914,0.002028151,0.001266128,0.0002651538,0.00004792048,0.00002179992,0.0002855625,0.00006626543,0.001427627],"genre_scores_gemma":[0.9978654,0.0003554399,0.0003659872,0.00004257205,0.00001019636,0.00001357773,0.0002927643,0.000009190656,0.001044891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00197206,"threshold_uncertainty_score":0.006597161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01784963992617164,"score_gpt":0.2770881611190541,"score_spread":0.2592385211928824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}