{"id":"W2065646551","doi":"10.1074/jbc.m204078200","title":"MDM2 Inhibits PCAF (p300/CREB-binding Protein-associated Factor)-mediated p53 Acetylation","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"PCAF; Acetylation; Mdm2; P300-CBP Transcription Factors; CREB-binding protein; Cancer research; Chemistry; Immunoprecipitation; Molecular biology; Biology; Transcription factor; CREB; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002805651,0.000241647,0.0005297808,0.00006995582,0.00007400758,0.0000251407,0.0001519659,0.0005491623,0.00149968],"category_scores_gemma":[0.001999013,0.0001771097,0.0003027311,0.0003683871,0.0000997578,0.00007854176,0.00005197581,0.001006528,0.00005887899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004544857,"about_ca_system_score_gemma":0.00008018292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001560548,"about_ca_topic_score_gemma":2.588681e-7,"domain_scores_codex":[0.9981447,0.00006107047,0.0007247825,0.0002452593,0.0004577461,0.0003664568],"domain_scores_gemma":[0.9983758,0.00009316779,0.0007247287,0.000175357,0.0003097599,0.0003212396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001358508,0.0002706892,0.002184761,0.00003960927,0.0001328295,0.0002193316,0.00005257348,0.000004998659,0.9949249,0.000001034742,0.0007236466,0.001309788],"study_design_scores_gemma":[0.003068638,0.0005379638,0.003478218,0.0004745981,0.00007246854,0.0005591439,0.00005692224,0.0001629259,0.9892008,0.00002524256,0.002117866,0.0002451583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956261,0.0008103799,0.00005043204,0.0007898764,0.0001113457,0.0002213302,0.00002723742,0.00006996551,0.002293343],"genre_scores_gemma":[0.9983553,0.0001991778,0.0002206645,0.0001117524,0.0003168334,0.00000527887,0.0000545167,0.00002297261,0.0007135367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005724033,"threshold_uncertainty_score":0.9994131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03959010964188009,"score_gpt":0.2502104268766295,"score_spread":0.2106203172347494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}