{"id":"W2065767524","doi":"10.1371/journal.pone.0017450","title":"Prion Protein Polymorphisms Affect Chronic Wasting Disease Progression","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Prion Research Institute; Wisconsin Department of Natural Resources","keywords":"Chronic wasting disease; PRNP; Glutamine; Biology; Genotype; Allele; Incubation period; Incubation; Amino acid; Gene; Medicine; Disease; Internal medicine; Genetics; Prion protein; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001251322,0.0001569586,0.000123001,0.00003341779,0.0001180684,0.00002033286,0.0001817963,0.00008335135,0.0001692799],"category_scores_gemma":[0.0001351417,0.0001444908,0.00008438381,0.00006659593,0.00004635886,0.000006951088,0.0001666477,0.00008283011,0.00003546259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002466029,"about_ca_system_score_gemma":0.0001113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003353878,"about_ca_topic_score_gemma":0.000001863907,"domain_scores_codex":[0.998928,0.00006644233,0.0001505115,0.0003543581,0.0002074739,0.0002932672],"domain_scores_gemma":[0.9992666,0.000003437688,0.00009450975,0.0003636753,0.00004615895,0.0002256785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000200338,0.0006067128,0.009679938,0.0003001975,0.00007262157,0.00001125985,0.00001892021,4.895545e-7,0.9714572,0.00004263918,0.0000301922,0.01757949],"study_design_scores_gemma":[0.0004349733,0.0004297832,0.007200455,0.0010307,0.00007460919,9.385883e-7,0.000004092539,0.0001474608,0.9901625,0.00008639217,0.000183792,0.0002443115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785956,0.01976053,0.0003225155,0.0000720105,0.00002316635,0.0008059007,0.00001181946,0.00005101785,0.000357475],"genre_scores_gemma":[0.9955009,0.000691965,0.00286855,0.00004938149,0.000335061,0.0002247613,0.00006342718,0.00003370682,0.0002322018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01906856,"threshold_uncertainty_score":0.5892163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03924629225957923,"score_gpt":0.2455231332214947,"score_spread":0.2062768409619154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}