{"id":"W2065784891","doi":"10.1371/journal.pone.0013085","title":"Gene Expression Changes Associated with Resistance to Intravenous Corticosteroid Therapy in Children with Severe Ulcerative Colitis","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children; Izaak Walton Killam Health Centre; Children's Hospital of Eastern Ontario; Mount Sinai Hospital","funders":"National Institutes of Health; Bristol-Myers Squibb; Crohn's and Colitis Foundation of Canada; Crohn's and Colitis Foundation; AstraZeneca; Hospital for Sick Children","keywords":"Corticosteroid; Gene expression; Ulcerative colitis; Microarray; Medicine; Transcriptome; Gene; Gene expression profiling; Internal medicine; Biology; Bioinformatics; Immunology; Genetics; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001324545,0.0001714569,0.000328941,0.000509635,0.0001620171,0.0002976087,0.0001030803,0.0002473753,0.0006974975],"category_scores_gemma":[0.0005843023,0.0001088068,0.0001539042,0.0006470865,0.0002087383,0.00008853926,0.0001301225,0.000241532,0.00009897116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001907691,"about_ca_system_score_gemma":0.0001277262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008499519,"about_ca_topic_score_gemma":0.001113943,"domain_scores_codex":[0.9998171,0.00002927636,0.00001367698,0.00006525668,0.00003923472,0.00003551197],"domain_scores_gemma":[0.9995722,0.0001411942,0.0001908018,0.00001618231,0.0000340821,0.00004555065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007116795,0.00002919777,0.9524569,0.00007732909,0.00004622413,0.0004720484,0.0001765266,0.0002003456,0.03899442,0.00002263159,0.0001511132,0.006661501],"study_design_scores_gemma":[0.000004084724,0.0000945085,0.9975713,0.000004432539,0.00001929477,0.000541063,0.0001123081,0.0001097717,0.001350202,0.00001054672,0.0001805739,0.00000206399],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991204,0.0003122609,0.00009697344,0.00001511886,0.000001638412,0.00000387183,0.0003515376,0.000003655954,0.00009445453],"genre_scores_gemma":[0.9984767,0.0002524591,0.0004203244,0.00002725713,0.000006741063,0.00002037637,0.0006712868,0.000004229951,0.0001205497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008499519,"threshold_uncertainty_score":0.002333343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009509360940522318,"score_gpt":0.2004012689050612,"score_spread":0.1908919079645389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}