{"id":"W2065795373","doi":"10.3747/co.v15i5.371","title":"Histone Deacetylase Inhibitors as Novel Anticancer Therapeutics","year":2008,"lang":"en","type":"article","venue":"Current Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Histone deacetylase; Romidepsin; Medicine; Histone deacetylase inhibitor; Clinical trial; Pharmacology; Cancer research; Vorinostat; Cancer; Histone deacetylase 5; Histone; Biology; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004112026,0.0004806121,0.0005662409,0.0004869052,0.0002079598,0.0008815273,0.0004127407,0.0006369313,0.003648267],"category_scores_gemma":[0.0001965405,0.0001836416,0.0003332924,0.0004096371,0.0002877273,0.0007826206,0.0003695162,0.001262661,0.002283525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005552631,"about_ca_system_score_gemma":0.0002849874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002704714,"about_ca_topic_score_gemma":0.001056533,"domain_scores_codex":[0.9998583,0.00002643127,0.00001011354,0.0000288888,0.00005316377,0.00002312105],"domain_scores_gemma":[0.9999442,0.00001388618,0.000009083706,0.000004758302,0.00001539792,0.00001274454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006431948,0.0003623834,0.0005714869,0.003093805,0.0001094101,0.0007947245,0.0001516012,0.001250578,0.1294818,0.04836297,0.0386237,0.7765544],"study_design_scores_gemma":[0.000239546,0.0006748554,0.0009210273,0.0002643707,0.0000981459,0.001328552,0.00003843771,0.0006031196,0.04528131,0.006323329,0.9442004,0.00002696779],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.01437512,0.9411212,0.006415553,0.004479318,0.002260189,0.0001138824,0.0002304756,0.0002364674,0.0307678],"genre_scores_gemma":[0.08477039,0.8709357,0.006973148,0.004012411,0.001454652,0.0001515006,0.0004334908,0.00003784562,0.03123086],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003648267,"threshold_uncertainty_score":0.01220471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.113370612628487,"score_gpt":0.4334222229215943,"score_spread":0.3200516102931074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}