{"id":"W2065795638","doi":"10.3390/molecules18010914","title":"Synthesis of 5α-Androstane-17-spiro-δ-lactones with a 3-Keto, 3-Hydroxy, 3-Spirocarbamate or 3-Spiromorpholinone as Inhibitors of 17β-Hydroxysteroid Dehydrogenases","year":2013,"lang":"en","type":"article","venue":"Molecules","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Shionogi","keywords":"Chemistry; Androsterone; Androstane; Ketone; Steroid; Glucuronate; Stereochemistry; Alcohol; Organic chemistry; Biochemistry; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001906284,0.0004862459,0.0004270668,0.0002551716,0.000101644,0.0002134481,0.0003796208,0.0002840336,0.001510646],"category_scores_gemma":[0.0001302922,0.0001786559,0.000407809,0.0002344705,0.0001257727,0.0002164867,0.0002201722,0.0003571527,0.001145704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002359096,"about_ca_system_score_gemma":0.0003350638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004683948,"about_ca_topic_score_gemma":0.0008511767,"domain_scores_codex":[0.9998887,0.00001470869,0.00001487251,0.0000201277,0.0000267854,0.0000348016],"domain_scores_gemma":[0.9999139,0.000005696867,0.00001675648,0.000009453202,0.00001926461,0.00003477757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003355024,0.0001336823,0.0003680702,0.0002554557,0.00003252547,0.0003940797,0.00006367114,0.0009625523,0.9820353,0.0005417717,0.0002051718,0.01467222],"study_design_scores_gemma":[0.0002677383,0.003174714,0.002922463,0.00003870276,0.0001104698,0.0008587283,0.00004357959,0.001136554,0.9582151,0.0001609817,0.03301733,0.00005366831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9579595,0.01439953,0.01219718,0.0002041502,0.0002662409,0.0005813246,0.001974091,0.000352997,0.01206504],"genre_scores_gemma":[0.9705577,0.006325973,0.01280783,0.0001663126,0.00003990243,0.0001935751,0.001584875,0.00004422314,0.008279626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001510646,"threshold_uncertainty_score":0.005053639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005084523765813152,"score_gpt":0.2109421443683888,"score_spread":0.2058576206025757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}