{"id":"W2065795638","doi":"10.3390/molecules18010914","title":"Synthesis of 5α-Androstane-17-spiro-δ-lactones with a 3-Keto, 3-Hydroxy, 3-Spirocarbamate or 3-Spiromorpholinone as Inhibitors of 17β-Hydroxysteroid Dehydrogenases","year":2013,"lang":"en","type":"article","venue":"Molecules","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Shionogi","keywords":"Chemistry; Androsterone; Androstane; Ketone; Steroid; Glucuronate; Stereochemistry; Alcohol; Organic chemistry; Biochemistry; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001510117,0.0004842467,0.0006501888,0.0001561947,0.0000891618,0.00003304076,0.0003650413,0.0003807879,0.0001229092],"category_scores_gemma":[0.000136753,0.0003460486,0.0002478783,0.000291099,0.0004291623,0.00001889292,0.0001741769,0.000169397,0.00004741878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001915221,"about_ca_system_score_gemma":0.0001508069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003618638,"about_ca_topic_score_gemma":0.00004044343,"domain_scores_codex":[0.9977051,0.0001439492,0.0006507284,0.0005854073,0.0003991267,0.0005156623],"domain_scores_gemma":[0.9983462,0.0000831572,0.0004508497,0.000697032,0.0001946075,0.0002281238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007203759,0.0003098717,0.001804317,0.0001908771,0.0003825719,0.00008798585,0.00008110858,0.0001995172,0.9943351,0.00003543258,0.0008201693,0.001032726],"study_design_scores_gemma":[0.001014389,0.002036091,0.00078735,0.0002737198,0.0001750799,0.0003004666,0.0001661521,0.0001066339,0.9941564,0.00003141855,0.0005000029,0.0004522884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948492,0.002404661,0.0001099333,0.00009053834,0.00006816623,0.0006747347,0.00006199535,0.00003623508,0.001704535],"genre_scores_gemma":[0.9979808,0.0003165653,0.0006642893,0.0001298934,0.00007283715,0.0001368823,0.00007780656,0.00009464903,0.0005262245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003131652,"threshold_uncertainty_score":0.9998991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005084523765813152,"score_gpt":0.2109421443683888,"score_spread":0.2058576206025757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}