{"id":"W2065796189","doi":"10.1038/ng1631","title":"Genomic alterations in cultured human embryonic stem cells","year":2005,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":622,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials","funders":"","keywords":"Biology; Embryonic stem cell; Epigenetics; Genetics; Mutant; Mutation; Phenotype; Cell culture; Gene; Stem cell; DNA methylation; Cell biology; Molecular biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001561598,0.0001755173,0.0001342757,0.00008674895,0.0000975205,0.00004499319,0.0003713993,0.0005024502,0.00002877616],"category_scores_gemma":[0.000006012779,0.0001737112,0.00007769105,0.0001382909,0.00004656083,0.000003072697,0.0001613897,0.0004534667,0.00007738936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006452716,"about_ca_system_score_gemma":0.00008501721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000312573,"about_ca_topic_score_gemma":0.0003206635,"domain_scores_codex":[0.9986899,0.00007428851,0.000220104,0.0004223347,0.0002128729,0.0003804739],"domain_scores_gemma":[0.9992878,0.000005921491,0.00005216666,0.0004665337,0.00008532993,0.0001022715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001577746,0.00006745249,0.00145797,0.00001201856,0.000019393,0.000004409101,0.0000524874,0.001998887,0.9888377,0.00002567006,0.006220853,0.001287433],"study_design_scores_gemma":[0.0005920532,0.00009859172,0.003711584,0.000008289365,0.000008209026,0.000008868532,0.00002912809,0.000377793,0.8218178,0.00001672759,0.1731107,0.0002202836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897358,0.00743847,0.000111138,0.0003388964,0.0001577569,0.0003113023,0.00002898201,0.00001295273,0.001864741],"genre_scores_gemma":[0.9887585,0.0005703321,0.001873797,0.000377589,0.0005575287,0.00002014136,0.000119943,0.00003263663,0.007689517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1670199,"threshold_uncertainty_score":0.7083737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01064463289577991,"score_gpt":0.2815304612595475,"score_spread":0.2708858283637676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}