{"id":"W2065796189","doi":"10.1038/ng1631","title":"Genomic alterations in cultured human embryonic stem cells","year":2005,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":622,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials","funders":"","keywords":"Biology; Embryonic stem cell; Epigenetics; Genetics; Mutant; Mutation; Phenotype; Cell culture; Gene; Stem cell; DNA methylation; Cell biology; Molecular biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001335845,0.0001582719,0.0001667717,0.0004403802,0.0002172884,0.0003778189,0.0002048926,0.0002391755,0.002274651],"category_scores_gemma":[0.0004456074,0.0002014195,0.0002011311,0.0003316392,0.0001895619,0.0001889729,0.0002112304,0.0004210959,0.0007062592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002867053,"about_ca_system_score_gemma":0.0002046394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002000209,"about_ca_topic_score_gemma":0.002364942,"domain_scores_codex":[0.9997835,0.00004532875,0.00004221721,0.00004392911,0.00006348182,0.00002156929],"domain_scores_gemma":[0.9997247,0.0001090954,0.00003708267,0.00006624256,0.00004104841,0.00002195599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006544833,0.00001385933,0.0008045593,0.00002941908,0.00001093866,0.0002476205,0.00004609,0.0001995116,0.9960656,0.000161762,0.00009515333,0.002260196],"study_design_scores_gemma":[0.00001062641,0.000104014,0.01840659,0.000007343433,0.00003982723,0.0006375226,0.00009469459,0.0005254515,0.975073,0.0001392546,0.004956227,0.000005465239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980838,0.002336839,0.006956953,0.0002740448,0.0001267051,0.00006921818,0.003285251,0.0002136041,0.005899435],"genre_scores_gemma":[0.9897566,0.001107498,0.002358441,0.0001027361,0.00001644836,0.00005630165,0.002954339,0.00007339675,0.003574297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002274651,"threshold_uncertainty_score":0.007609487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01064463289577991,"score_gpt":0.2815304612595475,"score_spread":0.2708858283637676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}