{"id":"W2065802574","doi":"10.1371/journal.pone.0001224","title":"Simple Fluorescent Sensors Engineered with Catalytic DNA ‘MgZ’ Based on a Non-Classic Allosteric Design","year":2007,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Aptamer; Fluorophore; Chemistry; DNA; Allosteric regulation; Nucleic acid; RNA; Fluorescence; Biophysics; Substrate (aquarium); Deoxyribozyme; Cleavage (geology); Combinatorial chemistry; Divalent; Stereochemistry; Enzyme; Biochemistry; Biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021379,0.0002395582,0.0002419521,0.0001078267,0.00006628072,0.00001970156,0.0001301489,0.0001408371,0.000002230672],"category_scores_gemma":[0.00006196866,0.0001912297,0.00007374733,0.0002134362,0.00007383271,0.000002936576,0.00003156641,0.0001130851,0.000008479166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004374198,"about_ca_system_score_gemma":0.0000449336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000546776,"about_ca_topic_score_gemma":0.00001555379,"domain_scores_codex":[0.9986994,0.00003310659,0.0002048629,0.0004177004,0.000281633,0.0003632464],"domain_scores_gemma":[0.9991511,0.00003297839,0.00008657065,0.0004957221,0.0001096474,0.0001240467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004225668,0.0006137131,0.000315283,0.00002949995,0.0001602052,0.00002278306,0.000007911748,0.0001854871,0.9976139,0.000001017874,0.000161013,0.0004666286],"study_design_scores_gemma":[0.000471086,0.001061031,0.0007037625,0.00008015685,0.0001375153,0.000003738018,0.0000157001,0.005106054,0.9920067,0.000005238957,0.0001201148,0.0002888642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9529582,0.00002738329,0.04599632,0.0001268027,0.00001091741,0.0003986786,0.00001791315,0.00009623216,0.0003675215],"genre_scores_gemma":[0.9673122,0.00001906011,0.03181112,0.000295438,0.0001127688,0.0000101405,0.0001970329,0.00004065826,0.0002015962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01435396,"threshold_uncertainty_score":0.779812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01932321191615118,"score_gpt":0.2300454041840363,"score_spread":0.2107221922678851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}