{"id":"W2065813362","doi":"10.1016/j.exppara.2011.06.018","title":"ABC transporters influence sensitivity of Brugia malayi to moxidectin and have potential roles in drug resistance","year":2011,"lang":"en","type":"article","venue":"Experimental Parasitology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Brandon University","funders":"Natural Sciences and Engineering Research Council of Canada; Research Manitoba","keywords":"Moxidectin; Brugia malayi; Biology; Transporter; Efflux; ATP-binding cassette transporter; Drug resistance; Ivermectin; Multiple drug resistance; Pharmacology; Multidrug Resistance-Associated Proteins; Drug; Major facilitator superfamily; Microbiology; Gene; Filariasis; Immunology; Genetics; Helminths","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002076425,0.00019258,0.0004712872,0.0001518673,0.00004147173,0.000003082386,0.00006536661,0.000105829,0.00004629299],"category_scores_gemma":[0.000007437262,0.0001850422,0.00007035602,0.000112739,0.0002120124,0.00007843375,0.00001541191,0.0001454691,0.00000602509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000378609,"about_ca_system_score_gemma":0.00003320332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000515182,"about_ca_topic_score_gemma":0.0030891,"domain_scores_codex":[0.9987008,0.000074037,0.0003645819,0.0003880355,0.0001665022,0.0003060256],"domain_scores_gemma":[0.9994993,0.00002198032,0.00007653313,0.0002116775,0.00003180531,0.0001587646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002298595,0.0003300561,0.1943051,0.00005243951,0.00003311616,0.001082545,0.007559767,0.00001035943,0.7937344,0.00047453,0.00003199008,0.00008710939],"study_design_scores_gemma":[0.0009280973,0.00009090702,0.4539865,0.00008172113,0.00002039241,0.00006720121,0.00172243,0.000008736234,0.5428751,0.00006488857,0.00003058253,0.0001235177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969547,0.0004649422,0.0004655193,0.0001788806,0.0001261071,0.0003687146,0.000008501945,0.00002914143,0.001403525],"genre_scores_gemma":[0.9962103,0.0000147239,0.003215431,0.0002344124,0.00001902603,0.00002325403,0.000007004042,0.00001926288,0.0002565745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2596813,"threshold_uncertainty_score":0.7545803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00984179357583874,"score_gpt":0.274934738394025,"score_spread":0.2650929448181862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}