{"id":"W2065813362","doi":"10.1016/j.exppara.2011.06.018","title":"ABC transporters influence sensitivity of Brugia malayi to moxidectin and have potential roles in drug resistance","year":2011,"lang":"en","type":"article","venue":"Experimental Parasitology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Brandon University","funders":"Natural Sciences and Engineering Research Council of Canada; Research Manitoba","keywords":"Moxidectin; Brugia malayi; Biology; Transporter; Efflux; ATP-binding cassette transporter; Drug resistance; Ivermectin; Multiple drug resistance; Pharmacology; Multidrug Resistance-Associated Proteins; Drug; Major facilitator superfamily; Microbiology; Gene; Filariasis; Immunology; Genetics; Helminths","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008084157,0.0001572937,0.0001927204,0.0002180742,0.0001888702,0.0003495436,0.0001227823,0.0003509374,0.00168428],"category_scores_gemma":[0.0003126131,0.0001604494,0.0001656288,0.000133488,0.0002765587,0.0002257131,0.0001860185,0.0003970439,0.0003067594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004850476,"about_ca_system_score_gemma":0.0001411978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004678668,"about_ca_topic_score_gemma":0.003627682,"domain_scores_codex":[0.9998827,0.00002357144,0.000007292766,0.00001263792,0.000022684,0.00005121805],"domain_scores_gemma":[0.9998633,0.00004116137,0.00003334131,0.00001323136,0.0000266658,0.00002221548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003510414,0.00003128187,0.005448935,0.0000325745,0.000006508219,0.00006654661,0.00004776726,0.00005993871,0.9923193,0.00005496007,0.00004545001,0.001535563],"study_design_scores_gemma":[0.0000310222,0.0005258115,0.4912431,0.00001326705,0.00005708067,0.0007048962,0.0003628131,0.001672988,0.5034173,0.0001354647,0.001812019,0.00002416892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987263,0.0002159784,0.00009193688,0.00005639731,0.000005365181,0.000005553531,0.00008237318,0.000009530697,0.0008066316],"genre_scores_gemma":[0.9991531,0.000106554,0.00007540952,0.00001879305,0.000001820439,0.00000312768,0.00005241739,0.000002146391,0.0005866393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004678668,"threshold_uncertainty_score":0.009302855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00984179357583874,"score_gpt":0.274934738394025,"score_spread":0.2650929448181862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}