{"id":"W2065862344","doi":"10.1053/j.gastro.2013.09.049","title":"Formulated Minimal-Length Synthetic Small Hairpin RNAs Are Potent Inhibitors of Hepatitis C Virus in Mice With Humanized Livers","year":2013,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Hepatitis C virus; Virology; Viral load; In vivo; Plasminogen activator; Virus; Hepatitis C; Medicine; Biology; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020794,0.0002582346,0.0006986103,0.0004875702,0.00004291195,0.00001411214,0.000206869,0.0001596158,0.0005044831],"category_scores_gemma":[0.0001458507,0.0002216577,0.0001053232,0.0002111393,0.0002876169,0.0001069495,0.0001254699,0.0004275587,0.00013487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002011398,"about_ca_system_score_gemma":0.00007022536,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01129794,"about_ca_topic_score_gemma":0.0191606,"domain_scores_codex":[0.9976321,0.00023692,0.0005883927,0.0004357477,0.0003358292,0.0007710248],"domain_scores_gemma":[0.9988166,0.0000741742,0.0002320558,0.0003707837,0.0002678187,0.0002385472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001744205,0.000482801,0.9629049,0.000143128,0.0001639893,0.0003840367,0.0004482607,0.00002916609,0.03002219,0.000007289309,0.0005721835,0.003097792],"study_design_scores_gemma":[0.007937362,0.005971898,0.9704791,0.0005351607,0.00008675984,0.0001506471,0.0002307138,0.002150665,0.01196326,0.00001812202,0.0002991562,0.0001771233],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972631,0.00005488221,0.0001371075,0.00098933,0.0000802966,0.001016511,0.00002598952,0.00004816576,0.0003845776],"genre_scores_gemma":[0.9976266,0.0001856649,0.001345892,0.0004676974,0.00004675178,0.0001167434,0.00002678469,0.00004880022,0.0001350837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01805893,"threshold_uncertainty_score":0.9987372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01601180430712973,"score_gpt":0.2388805458345982,"score_spread":0.2228687415274685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}