{"id":"W2065879291","doi":"10.1159/000341438","title":"Interleukin-1 Induction of Aggrecanase Gene Expression in Human Articular Chondrocytes is Mediated by Mitogen-Activated Protein Kinases","year":2012,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Arthritis Network; Canadian Institutes of Health Research","keywords":"Aggrecanase; Pyrrolidine dithiocarbamate; p38 mitogen-activated protein kinases; Chemistry; ADAMTS; Molecular biology; MAPK/ERK pathway; Kinase; Phosphorylation; Protein kinase A; Cell biology; Signal transduction; Biology; Biochemistry; Thrombospondin; NF-κB; Metalloproteinase; Matrix metalloproteinase; Medicine; Osteoarthritis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001157288,0.0004454623,0.0001861872,0.0001720766,0.000122902,0.0001757948,0.00008460522,0.0001606087,0.001342948],"category_scores_gemma":[0.00009230848,0.0001185285,0.0003726723,0.0001220552,0.0001521746,0.0001433398,0.0001089831,0.0003000174,0.0004442868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000195357,"about_ca_system_score_gemma":0.0001636464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004710653,"about_ca_topic_score_gemma":0.0006428708,"domain_scores_codex":[0.9998676,0.00002246664,0.00001507462,0.00002732073,0.00003109416,0.00003648603],"domain_scores_gemma":[0.9999375,0.0000100049,0.00002098258,0.000007089654,0.00001425035,0.00001007301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001938992,0.0000214593,0.0001977773,0.00008721905,0.00000318698,0.00004751144,0.00001399323,0.00001719613,0.9985793,0.00001483774,0.00002426174,0.0007993003],"study_design_scores_gemma":[0.00005132385,0.0008178682,0.01870015,0.00001468103,0.00003715607,0.0004860543,0.00006466125,0.0004941906,0.9761959,0.00005357903,0.003076656,0.000007769899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859343,0.009427752,0.002705591,0.0001295059,0.00005923675,0.00005521882,0.0005184414,0.00005517371,0.001114776],"genre_scores_gemma":[0.9909259,0.003622548,0.002036049,0.0000506588,0.00003325795,0.00008015231,0.000786385,0.000006105623,0.002458909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001342948,"threshold_uncertainty_score":0.00449264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009697197426628971,"score_gpt":0.2278275254424278,"score_spread":0.2181303280157988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}