{"id":"W2065879291","doi":"10.1159/000341438","title":"Interleukin-1 Induction of Aggrecanase Gene Expression in Human Articular Chondrocytes is Mediated by Mitogen-Activated Protein Kinases","year":2012,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Arthritis Network; Canadian Institutes of Health Research","keywords":"Aggrecanase; Pyrrolidine dithiocarbamate; p38 mitogen-activated protein kinases; Chemistry; ADAMTS; Molecular biology; MAPK/ERK pathway; Kinase; Phosphorylation; Protein kinase A; Cell biology; Signal transduction; Biology; Biochemistry; Thrombospondin; NF-κB; Metalloproteinase; Matrix metalloproteinase; Medicine; Osteoarthritis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005170627,0.0001588072,0.0002638203,0.00004509958,0.00004265027,0.000002478919,0.00003788051,0.0002343801,0.0001101077],"category_scores_gemma":[0.00002494891,0.0001341832,0.00004997409,0.00008906188,0.0001156366,0.00005523717,0.00003521929,0.0001343111,0.000003285066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002892308,"about_ca_system_score_gemma":0.00001950662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001558547,"about_ca_topic_score_gemma":3.264266e-7,"domain_scores_codex":[0.9992324,0.00003362857,0.0002018904,0.0002302128,0.00007826721,0.0002236226],"domain_scores_gemma":[0.9995575,0.00001117887,0.000108072,0.0001763602,0.00003314797,0.0001137504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001801299,0.0003441561,0.0008562819,0.0001236972,0.00002485871,0.00001027405,0.0002112756,2.453226e-8,0.9978369,0.000001157385,0.00007586576,0.0003354176],"study_design_scores_gemma":[0.001796767,0.0003125834,0.0002949459,0.0002178642,0.00003488862,0.00001655458,0.0001334083,0.000001203141,0.9969396,0.00002110388,0.0001099129,0.000121145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961467,0.003451822,0.000003464045,0.0000316462,0.00006613825,0.0002335038,0.00002509256,0.00001970363,0.00002187026],"genre_scores_gemma":[0.9986631,0.00003966433,0.00008347348,0.00003493734,0.00009153589,0.00004036456,0.0007461291,0.00001282184,0.0002879279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003412158,"threshold_uncertainty_score":0.5471832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009697197426628971,"score_gpt":0.2278275254424278,"score_spread":0.2181303280157988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}