{"id":"W2065900855","doi":"10.1182/blood.v99.9.3256","title":"Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary structure","year":2002,"lang":"en","type":"article","venue":"Blood","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Epitope; Monoclonal antibody; Biology; Molecular biology; Antibody; Antigen; Epitope mapping; Peptide sequence; CD20; Virology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002238546,0.0003185876,0.0005305746,0.00008321115,0.000170755,0.0000426036,0.0002064377,0.0001583961,0.0004532986],"category_scores_gemma":[0.0002200173,0.0002255315,0.00009954526,0.0001148269,0.0004693419,0.00013279,0.0001026739,0.0002875853,0.00000254421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001796555,"about_ca_system_score_gemma":0.00003078686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008325821,"about_ca_topic_score_gemma":0.00006641395,"domain_scores_codex":[0.9977338,0.0001111905,0.0005356694,0.0005305986,0.0005917278,0.0004970385],"domain_scores_gemma":[0.9989012,0.0003842932,0.0001443466,0.0002555981,0.000131369,0.0001832236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006590682,0.001288798,0.5532663,0.0007992783,0.0001422343,0.0002940939,0.0003489332,1.788201e-7,0.4260325,0.00006584022,0.01506614,0.002036506],"study_design_scores_gemma":[0.01004899,0.002841748,0.3929983,0.0008043588,0.0003793226,0.00180939,0.0001737846,0.004271585,0.5776663,0.001240722,0.006869745,0.0008957227],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790706,0.006123397,0.00002017043,0.00193266,0.00003426144,0.0006569591,0.01211421,0.00001291767,0.00003484868],"genre_scores_gemma":[0.9965537,0.0006436955,0.001411993,0.0003269522,0.0001588094,0.00005378518,0.0005756691,0.00002447453,0.0002509145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.160268,"threshold_uncertainty_score":0.9196909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05697412030067603,"score_gpt":0.3220806868397376,"score_spread":0.2651065665390615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}