{"id":"W2065900855","doi":"10.1182/blood.v99.9.3256","title":"Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary structure","year":2002,"lang":"en","type":"article","venue":"Blood","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Epitope; Monoclonal antibody; Biology; Molecular biology; Antibody; Antigen; Epitope mapping; Peptide sequence; CD20; Virology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001543515,0.000322744,0.0001820009,0.0001577675,0.0001551302,0.0002450076,0.000146332,0.0002875416,0.0009637448],"category_scores_gemma":[0.0001418903,0.0001332669,0.0001611059,0.0001032614,0.0001892969,0.0001349145,0.0002208964,0.0003403398,0.0004652416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002212096,"about_ca_system_score_gemma":0.000167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002365786,"about_ca_topic_score_gemma":0.0002843222,"domain_scores_codex":[0.9998281,0.00003831341,0.00001685865,0.00002962992,0.00004896118,0.00003814836],"domain_scores_gemma":[0.9998759,0.00001966046,0.00003806816,0.000009687205,0.00001184207,0.00004491501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006289134,0.000006413258,0.0002521194,0.00001800939,0.000002160961,0.00006359276,0.000008033983,0.0000336513,0.9986379,0.00006431863,0.000009482176,0.0008414896],"study_design_scores_gemma":[0.00002526633,0.0003168756,0.01075748,0.000006339963,0.00001477201,0.001438659,0.00002613965,0.000456389,0.9835279,0.0001017688,0.00332219,0.000006274334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966008,0.0007545225,0.001611928,0.00003107379,0.000007888298,0.00001225639,0.00006343998,0.00002488939,0.000893301],"genre_scores_gemma":[0.9972058,0.0003256256,0.001604509,0.00003245725,0.000005123371,0.000009711125,0.0001983146,0.000007086784,0.0006113185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009637448,"threshold_uncertainty_score":0.003224075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05697412030067603,"score_gpt":0.3220806868397376,"score_spread":0.2651065665390615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}