{"id":"W2065920350","doi":"10.1128/jvi.02706-06","title":"Unique Thermodynamic Response of Tipranavir to Human Immunodeficiency Virus Type 1 Protease Drug Resistance Mutations","year":2007,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"National Institute of General Medical Sciences; National Institutes of Health; Boehringer Ingelheim","keywords":"Biology; Protease; HIV-1 protease; Mutant; Virology; Isothermal titration calorimetry; Protease inhibitor (pharmacology); Biochemistry; Virus; Enzyme; Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001380885,0.0002678735,0.0003008753,0.0001631502,0.000211655,0.0002462425,0.0002556133,0.0002442551,0.001776941],"category_scores_gemma":[0.0005220324,0.0001217491,0.0001538869,0.0001357684,0.0002291752,0.0001541848,0.0002054231,0.0003065974,0.000282175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002054539,"about_ca_system_score_gemma":0.0001027658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003828773,"about_ca_topic_score_gemma":0.0003701669,"domain_scores_codex":[0.9998091,0.00003657042,0.000005906441,0.00004711858,0.00006104399,0.00004025456],"domain_scores_gemma":[0.9998651,0.00004795858,0.0000219513,0.000009816124,0.00003426337,0.00002102645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005957184,0.00006598257,0.002473267,0.00008806233,0.00003394872,0.0001850606,0.00007698211,0.002752129,0.9869083,0.0002977142,0.000301163,0.006221497],"study_design_scores_gemma":[0.00004481907,0.0007238918,0.02274463,0.00001253897,0.00003194512,0.0008001684,0.00008009608,0.02399792,0.9485251,0.0004121139,0.002577905,0.00004889032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944828,0.0007601131,0.002022912,0.00007489372,0.00003139543,0.00001705131,0.000246875,0.0001007008,0.002263274],"genre_scores_gemma":[0.9988137,0.0001540239,0.0004258336,0.00003192351,0.000008968171,0.000009860022,0.0001476967,0.00001425822,0.0003937123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001776941,"threshold_uncertainty_score":0.005944431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01205143521190668,"score_gpt":0.3110769952820948,"score_spread":0.2990255600701882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}