{"id":"W2065946034","doi":"10.1002/anie.200501399","title":"Regio‐ and Chemoselective 6′‐N‐Derivatization of Aminoglycosides: Bisubstrate Inhibitors as Probes To Study Aminoglycoside 6′‐<i>N</i>‐Acetyltransferases","year":2005,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; McMaster University","keywords":"Acetyltransferases; Aminoglycoside; Acetyltransferase; Chemistry; Regioselectivity; Derivatization; Enzyme; Combinatorial chemistry; Acetylation; Antibiotics; Biochemistry; Stereochemistry; Chromatography; Mass spectrometry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001236476,0.0002189413,0.0002663733,0.0002447302,0.00006911991,0.00003173831,0.00007651145,0.00007327365,0.0001422314],"category_scores_gemma":[0.0001280165,0.0002010193,0.00006218749,0.0002710042,0.00005643905,0.0002827664,0.00003125448,0.000103783,0.00002625836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001883092,"about_ca_system_score_gemma":0.00007963095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004347902,"about_ca_topic_score_gemma":0.0000486854,"domain_scores_codex":[0.9985588,0.00001746703,0.0004092916,0.0003651451,0.0004783592,0.0001709536],"domain_scores_gemma":[0.9991946,0.00006468336,0.0001169246,0.0001311553,0.0003639419,0.0001286469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001228234,0.003848157,0.1226457,0.0001303077,0.001193543,0.0000793801,0.01364687,0.00002327432,0.8317612,0.0002751529,0.0109503,0.01421791],"study_design_scores_gemma":[0.00222714,0.0003254128,0.02126128,0.0001962345,0.0001246878,0.00005260013,0.0009781143,0.000018382,0.9727978,0.0001409753,0.001702674,0.0001747169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910385,0.00007600243,0.0007209177,0.004956818,0.0001611032,0.0008676814,0.0000236254,0.00006968231,0.002085692],"genre_scores_gemma":[0.995617,0.0001171164,0.00149687,0.0003455672,0.000555499,0.0001806843,0.0003182434,0.00002497174,0.0013441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1410366,"threshold_uncertainty_score":0.8197328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252876882469563,"score_gpt":0.2764657625477379,"score_spread":0.2639369937230423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}