{"id":"W2065946034","doi":"10.1002/anie.200501399","title":"Regio‐ and Chemoselective 6′‐N‐Derivatization of Aminoglycosides: Bisubstrate Inhibitors as Probes To Study Aminoglycoside 6′‐<i>N</i>‐Acetyltransferases","year":2005,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; McMaster University","keywords":"Acetyltransferases; Aminoglycoside; Acetyltransferase; Chemistry; Regioselectivity; Derivatization; Enzyme; Combinatorial chemistry; Acetylation; Antibiotics; Biochemistry; Stereochemistry; Chromatography; Mass spectrometry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002431072,0.0005306178,0.0002419912,0.0001101153,0.0001419377,0.0001888203,0.0003775943,0.0003889296,0.000823159],"category_scores_gemma":[0.0001627665,0.0002485899,0.0001958087,0.0001320703,0.0002410392,0.0002364727,0.0001610824,0.0005660119,0.0003694642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004634517,"about_ca_system_score_gemma":0.0002116368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009701114,"about_ca_topic_score_gemma":0.00158016,"domain_scores_codex":[0.9998327,0.0000326728,0.00001270994,0.00003938176,0.00004856052,0.000033861],"domain_scores_gemma":[0.9999287,0.00001330031,0.00002446069,0.00001154635,0.00001107485,0.00001087826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002817365,0.00001035263,0.0000232058,0.00001807392,0.00000192384,0.00001204444,0.00001001005,0.00006342719,0.9992278,0.0001028632,0.00001617059,0.0004858477],"study_design_scores_gemma":[0.000002850565,0.00003073503,0.00008027891,4.769291e-7,0.000001835202,0.00002462759,0.000001963291,0.000113893,0.9993333,0.000007473187,0.0004010873,0.000001468698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675853,0.001898313,0.02534012,0.0001127093,0.00003877753,0.0001225117,0.0003733578,0.0001661068,0.004362875],"genre_scores_gemma":[0.9822,0.001389205,0.01270315,0.00005430434,0.000008762896,0.00009158227,0.0003057392,0.00003773595,0.003209522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009701114,"threshold_uncertainty_score":0.003362596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252876882469563,"score_gpt":0.2764657625477379,"score_spread":0.2639369937230423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}