{"id":"W2065957015","doi":"10.1097/gim.0b013e318133fb1b","title":"The pharmacology of multiple regimens of agalsidase alfa enzyme replacement therapy for Fabry disease","year":2007,"lang":"en","type":"article","venue":"Genetics in Medicine","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Centre Hospitalier Universitaire de Sherbrooke; Dalhousie University; Hospital for Sick Children; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health","keywords":"Enzyme replacement therapy; Fabry disease; Medicine; Pharmacology; Pharmacotherapy; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00180127,0.0001373706,0.0003720035,0.0001712454,0.00005511505,0.000001458634,0.0002097734,0.00006872747,0.0001121776],"category_scores_gemma":[0.0008776611,0.00008849151,0.00007314312,0.0002764582,0.0005277052,0.00001005426,0.00005579687,0.0001699315,0.000001228394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007598607,"about_ca_system_score_gemma":0.0001465174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006462499,"about_ca_topic_score_gemma":0.00006068707,"domain_scores_codex":[0.9981163,0.00007623775,0.0006180018,0.0002462816,0.0005412296,0.0004020107],"domain_scores_gemma":[0.9978905,0.0009816184,0.0001705569,0.0004480475,0.0003057023,0.0002035666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03609752,0.001787572,0.1785933,0.0009427503,0.0004812549,0.0001635263,0.003363353,0.0001561408,0.6224672,0.0003729589,0.03723396,0.1183404],"study_design_scores_gemma":[0.07059374,0.01044165,0.1883105,0.0006375851,0.0003551036,0.00002349038,0.004147822,0.007123466,0.5686229,0.001425643,0.147891,0.0004270936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9624852,0.02687985,0.002753368,0.004993913,0.0003499977,0.002055111,0.00001430801,0.00001089263,0.0004573777],"genre_scores_gemma":[0.9925759,0.005130456,0.0006861673,0.0005944158,0.000271607,0.00007427618,0.00002571997,0.00002528675,0.0006161846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1179133,"threshold_uncertainty_score":0.3608579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04741803235073011,"score_gpt":0.3917617246892968,"score_spread":0.3443436923385667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}