{"id":"W2065984159","doi":"10.3109/1061186x.2012.655247","title":"Nucleic-acid based gene therapeutics: delivery challenges and modular design of nonviral gene carriers and expression cassettes to overcome intracellular barriers for sustained targeted expression","year":2012,"lang":"en","type":"review","venue":"Journal of drug targeting","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Gene delivery; Transfection; Nucleic acid; Gene expression; Cell biology; Endosome; Biology; Intracellular; Transgene; Gene silencing; Gene knockdown; Genetic enhancement; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007388238,0.0010798,0.001426837,0.001137264,0.0002442626,0.000876704,0.001148294,0.001518327,0.001131149],"category_scores_gemma":[0.0003295866,0.0004360242,0.0004591185,0.001172895,0.000947332,0.001560173,0.0005363682,0.001981667,0.001618259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009680566,"about_ca_system_score_gemma":0.0006772372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005698854,"about_ca_topic_score_gemma":0.000658576,"domain_scores_codex":[0.9997146,0.00004627685,0.00002413359,0.00005683568,0.0001315312,0.0000265135],"domain_scores_gemma":[0.9998738,0.0000507485,0.00002589544,0.000009534506,0.00002818375,0.0000119186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007594284,0.0001707763,0.0001445305,0.01553026,0.00007338995,0.0006644516,0.0001932692,0.001961547,0.2340729,0.03227283,0.007481734,0.7073584],"study_design_scores_gemma":[0.00003805418,0.0003533371,0.0006629546,0.00119177,0.00009335834,0.003375867,0.00007831075,0.001102626,0.08055266,0.005768664,0.9067296,0.0000528466],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002454763,0.9842187,0.009657694,0.0004149561,0.0002451948,0.00004034563,0.00002190303,0.00007025974,0.002876091],"genre_scores_gemma":[0.01022529,0.974106,0.01048857,0.0004043083,0.0001263394,0.00009269814,0.00006245208,0.0000174531,0.004477004],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001518327,"threshold_uncertainty_score":0.007023752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03325400556586686,"score_gpt":0.2761109209948253,"score_spread":0.2428569154289585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}