{"id":"W2065984159","doi":"10.3109/1061186x.2012.655247","title":"Nucleic-acid based gene therapeutics: delivery challenges and modular design of nonviral gene carriers and expression cassettes to overcome intracellular barriers for sustained targeted expression","year":2012,"lang":"en","type":"review","venue":"Journal of drug targeting","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Gene delivery; Transfection; Nucleic acid; Gene expression; Cell biology; Endosome; Biology; Intracellular; Transgene; Gene silencing; Gene knockdown; Genetic enhancement; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001169908,0.0004951444,0.001168042,0.0002449577,0.0001359183,0.00003730821,0.0003279009,0.0004178032,0.000007885057],"category_scores_gemma":[0.0002044604,0.0003939545,0.0003666996,0.00006681652,0.00008198291,0.0000340207,0.0001712113,0.0002776403,3.117244e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005081775,"about_ca_system_score_gemma":0.0002598266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002577628,"about_ca_topic_score_gemma":3.741433e-7,"domain_scores_codex":[0.9975066,0.0004094901,0.0009528722,0.0004273024,0.0002607791,0.0004429591],"domain_scores_gemma":[0.9978307,0.000123974,0.00104011,0.0002910198,0.0003707204,0.0003434243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003254134,0.0000356352,0.00001920774,0.002155294,0.000273376,0.00001347418,0.0005462255,0.000174022,0.9507006,5.314292e-7,0.0002029049,0.04555326],"study_design_scores_gemma":[0.0009638139,0.000900866,0.000007600191,0.002941897,0.0008530568,0.00005810062,0.001323852,0.0003069643,0.9147135,0.0000153139,0.07723096,0.0006840753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09956807,0.8927285,0.006820065,0.0000383066,0.0002151099,0.0005573606,0.00006634049,0.000004714039,0.000001554192],"genre_scores_gemma":[0.08225697,0.8940391,0.02289856,0.00007207035,0.0005322574,0.00002823283,0.0000722667,0.00008630152,0.00001421994],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.07702805,"threshold_uncertainty_score":0.9998512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03325400556586686,"score_gpt":0.2761109209948253,"score_spread":0.2428569154289585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}