{"id":"W2065987383","doi":"10.1016/j.nbd.2015.02.009","title":"From molecule to molecule and cell to cell: Prion-like mechanisms in amyotrophic lateral sclerosis","year":2015,"lang":"en","type":"review","venue":"Neurobiology of Disease","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"School of Nursing, University of British Columbia; Canadian Institutes of Health Research; PrioNet Canada; Temerty Family Foundation; University of British Columbia","keywords":"Amyotrophic lateral sclerosis; SOD1; Biology; Protein aggregation; Neuroscience; Neurodegeneration; Protein folding; Motor neuron; Disease; Neurotoxicity; Cell biology; Medicine; Pathology; Spinal cord; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005537162,0.0008934767,0.001402071,0.001771762,0.0003036871,0.001196488,0.0008273582,0.001343607,0.002416881],"category_scores_gemma":[0.0005445749,0.0002295934,0.0003528081,0.001814821,0.0007063561,0.001657031,0.0009122998,0.001695057,0.001242707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005374178,"about_ca_system_score_gemma":0.001091518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001188799,"about_ca_topic_score_gemma":0.002395197,"domain_scores_codex":[0.9998699,0.00002157784,0.00001997155,0.00002046822,0.00005187038,0.00001614634],"domain_scores_gemma":[0.999779,0.00009537027,0.00003562979,0.000005841764,0.00005795355,0.00002615471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001088453,0.00006115273,0.0002194335,0.01610825,0.0001027381,0.0003535289,0.0001198441,0.0003930386,0.003241188,0.006156084,0.04135248,0.9317834],"study_design_scores_gemma":[0.00002192058,0.00006790968,0.0008448652,0.003646879,0.0001414231,0.00126335,0.0001087195,0.00008822007,0.0004086372,0.004666928,0.9887156,0.00002556527],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007172922,0.9990904,0.0000707941,0.0002235931,0.0001575161,0.000001586038,0.000008161934,0.000003355102,0.0003727788],"genre_scores_gemma":[0.0004687409,0.9988565,0.00008189754,0.0001238432,0.00016846,0.000001936127,0.00001081682,4.815541e-7,0.0002873215],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002416881,"threshold_uncertainty_score":0.008085251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0506046569690586,"score_gpt":0.3182045435069255,"score_spread":0.2675998865378669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}