{"id":"W2066036573","doi":"10.1021/jo4012442","title":"Synthesis and Immunological Characterization of Modified Hyaluronic Acid Hexasaccharide Conjugates","year":2013,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Chemistry; Glycoconjugate; Immunogenicity; Conjugate; Toxoid; Hapten; Residue (chemistry); Epitope; Stereochemistry; Moiety; HEXA; Glycopeptide; Biochemistry; Hyaluronic acid; Diphtheria toxin; Antibody; Toxin; Immunization; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001479743,0.0003309355,0.0001670684,0.0002025091,0.0001131706,0.0001938356,0.0001336957,0.0001860316,0.0008728281],"category_scores_gemma":[0.0002418002,0.00009809398,0.0001547586,0.0002178406,0.0001272955,0.0001620611,0.0001529357,0.0003063713,0.0003619025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001865238,"about_ca_system_score_gemma":0.0001694151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003818415,"about_ca_topic_score_gemma":0.0003070043,"domain_scores_codex":[0.9998904,0.0000249861,0.00001190097,0.00001399793,0.00004158824,0.00001707647],"domain_scores_gemma":[0.9998511,0.00002552436,0.00002867349,0.00001589489,0.0000385011,0.00004018188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002657066,0.0000136433,0.00006988391,0.00001447729,0.00000229945,0.00003974262,0.000009366267,0.0000601137,0.9990496,0.00003876675,0.000004518816,0.0006710522],"study_design_scores_gemma":[0.000005659173,0.0002177465,0.001191133,0.000002732005,0.000007510855,0.00009992455,0.000009299831,0.0001966377,0.9969146,0.00002664419,0.001325009,0.000003007155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876351,0.001111389,0.008861089,0.00004329793,0.00002273463,0.00008610691,0.0002662955,0.00002485998,0.001949142],"genre_scores_gemma":[0.9853379,0.001099319,0.008472504,0.00005968486,0.00001440028,0.00005884808,0.0009476636,0.00003290568,0.003976778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008728281,"threshold_uncertainty_score":0.002919853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008881554243356933,"score_gpt":0.2182561630775592,"score_spread":0.2093746088342022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}