{"id":"W2066045650","doi":"10.1038/mtna.2013.20","title":"Optimization of Ultrasound-mediated Anti-angiogenic Cancer Gene Therapy","year":2013,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Krembil Foundation; University of Toronto","keywords":"Microbubbles; Gene knockdown; Gene silencing; Cancer research; Angiogenesis; Medicine; Neovascularization; Genetic enhancement; Small hairpin RNA; Perfusion; Ultrasound; Cancer; Pathology; Biology; Internal medicine; Gene; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003366062,0.0004425955,0.0002750569,0.0002554249,0.00009280202,0.0003514029,0.0002722405,0.0003040264,0.0007777094],"category_scores_gemma":[0.0003385386,0.0001715835,0.0001803777,0.0002368011,0.0001834462,0.0002228116,0.0001667001,0.0004156946,0.000213546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004221272,"about_ca_system_score_gemma":0.0002647268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004825076,"about_ca_topic_score_gemma":0.0007144521,"domain_scores_codex":[0.9997488,0.0000387279,0.0000199496,0.00005227022,0.00009305999,0.00004726316],"domain_scores_gemma":[0.999848,0.0000497611,0.00005422802,0.000008009289,0.00002202012,0.00001791119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009399554,0.00006312181,0.00016888,0.00004806205,0.00000474416,0.00001942709,0.00001757729,0.001142948,0.9938444,0.0001123577,0.00004178026,0.004442845],"study_design_scores_gemma":[0.00001216692,0.000598798,0.001306924,0.000004094456,0.00001516201,0.00003518556,0.000010957,0.005290188,0.9913019,0.00002456507,0.001393102,0.000006902726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589132,0.003018125,0.03548708,0.00008298748,0.00004638168,0.0001962401,0.0001754692,0.0002293317,0.001851132],"genre_scores_gemma":[0.9794377,0.001485193,0.01719144,0.0000446901,0.00001269313,0.0002391798,0.0001618784,0.00003657057,0.001390573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007777094,"threshold_uncertainty_score":0.003062725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007133023728704242,"score_gpt":0.2058646890681221,"score_spread":0.1987316653394179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}