{"id":"W2066050863","doi":"10.1021/jo052539r","title":"A New Class of Glucosidase Inhibitor:  Analogues of the Naturally Occurring Glucosidase Inhibitor Salacinol with Different Ring Heteroatom Substituents and Acyclic Chain Extension","year":2006,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Chemistry; Stereochemistry; Heteroatom; Sulfonium; Maltase; Stereocenter; Ring (chemistry); Iminium; Enzyme; Enantioselective synthesis; Organic chemistry; Salt (chemistry)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002542352,0.0003847635,0.0006109454,0.00003524155,0.0001356229,0.00003998107,0.000575647,0.0002110258,0.000152521],"category_scores_gemma":[0.0001578644,0.0002213693,0.000229507,0.0002324966,0.0002526013,0.0001262215,0.0002456234,0.0006888337,3.972951e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000155462,"about_ca_system_score_gemma":0.0001503867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004910149,"about_ca_topic_score_gemma":0.0000280682,"domain_scores_codex":[0.9978329,0.00004399528,0.0009175382,0.0002518666,0.0006371732,0.0003165275],"domain_scores_gemma":[0.9975337,0.000248468,0.001224792,0.0006258474,0.0002010706,0.0001661037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000354543,0.0001382377,0.007411241,0.0004968601,0.0001226038,0.00002524871,0.00026717,0.0000253569,0.9908183,0.000001283102,0.00009600726,0.0002431237],"study_design_scores_gemma":[0.001537976,0.00002482984,0.002725808,0.001371419,0.000296443,0.0006249414,0.0004787486,0.00005269052,0.9925724,0.00004572364,0.00003373778,0.0002352366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978969,0.001514791,0.00003106907,0.000152967,0.00006750393,0.00006729049,0.00002172113,0.00001903804,0.0002287131],"genre_scores_gemma":[0.9991803,0.00009235533,0.00004651552,0.00001882819,0.000468613,0.000001080376,0.000005543467,0.0000411718,0.000145609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004685432,"threshold_uncertainty_score":0.9027178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006194625072767146,"score_gpt":0.189754164610579,"score_spread":0.1835595395378118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}