{"id":"W2066052557","doi":"10.1038/444045a","title":"Second step to retinal tumours","year":2006,"lang":"en","type":"letter","venue":"Nature","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"MDMX; Retinoblastoma; Gene; Cancer research; Biology; Suppressor; Mutation; Retinoblastoma protein; Mdm2; Cell growth; Tumor suppressor gene; Cancer; Carcinogenesis; Cell cycle; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006691279,0.0005084928,0.000612235,0.0005144248,0.00173944,0.002020255,0.0006315251,0.01574597,0.009126914],"category_scores_gemma":[0.004223045,0.0002406312,0.0007958224,0.0002219133,0.001349735,0.002011955,0.001200961,0.01495751,0.002779472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001927133,"about_ca_system_score_gemma":0.001068158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001304895,"about_ca_topic_score_gemma":0.001986535,"domain_scores_codex":[0.9994451,0.0001235894,0.00003922716,0.00009269351,0.0001311978,0.0001682458],"domain_scores_gemma":[0.9991135,0.0003544693,0.00007927687,0.0001267694,0.0001333844,0.0001925676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004266347,0.000111839,0.002212302,0.0002648557,0.00008478532,0.07299766,0.0002047006,0.0002395014,0.00331895,0.05921542,0.8129036,0.0480198],"study_design_scores_gemma":[0.0002687315,0.0001425181,0.001651271,0.0002639969,0.00006460187,0.1121334,0.0002450903,0.001056243,0.002133075,0.04436472,0.8376289,0.00004743008],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01014766,0.02499174,0.002178852,0.8598638,0.0450833,0.00005384719,0.0001230456,0.0002758121,0.05728192],"genre_scores_gemma":[0.1586622,0.01164816,0.003880498,0.6619704,0.07629953,0.0001226926,0.0001384337,0.0001153723,0.08716271],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01574597,"threshold_uncertainty_score":0.03053254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005310383474790599,"score_gpt":0.2427255608030205,"score_spread":0.2374151773282299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}