{"id":"W2066082644","doi":"10.1073/pnas.1415789111","title":"Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":393,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; European Research Council; Canadian Institutes of Health Research; Direktoratet for Utviklingssamarbeid; Department for International Development; National Institutes of Health; United States Agency for International Development; European Molecular Biology Organization; Udenrigsministeriet; International AIDS Vaccine Initiative; Aids Fonds; Irish Aid; Bill and Melinda Gates Foundation","keywords":"Trimer; Antibody; Context (archaeology); Recombinant DNA; Virology; Antigen; Biology; Chemistry; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404918,0.0002048076,0.0001564268,0.0001433566,0.00008719922,0.0001860504,0.0001548663,0.0001664974,0.0007897433],"category_scores_gemma":[0.0001643513,0.00009719916,0.0001322831,0.0001177505,0.00009694941,0.00009228929,0.0001871946,0.0003995597,0.0003513277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001483228,"about_ca_system_score_gemma":0.00009215501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004956101,"about_ca_topic_score_gemma":0.0006815299,"domain_scores_codex":[0.9998915,0.000021201,0.000005996893,0.00001944072,0.00003380052,0.00002801237],"domain_scores_gemma":[0.9999206,0.00002492512,0.00001543913,0.00001289858,0.00001010348,0.00001595866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003811627,0.00001396449,0.000674492,0.000007979492,0.000002253266,0.0000189432,0.000006170156,0.0000522284,0.9978187,0.00003247394,0.00003622645,0.001298471],"study_design_scores_gemma":[0.00001969667,0.000535488,0.01429006,0.000005501478,0.00002003766,0.0006874173,0.00002455443,0.002065954,0.9802216,0.00004919635,0.002076965,0.000003532051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959872,0.0002656931,0.002405261,0.00002356135,0.000005834912,0.00002406737,0.0001278365,0.00004388196,0.001116503],"genre_scores_gemma":[0.9944528,0.0002160612,0.003572899,0.00006198301,0.000006226725,0.00001092558,0.0005318155,0.00001327184,0.001133853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007897433,"threshold_uncertainty_score":0.002641916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03807084139699523,"score_gpt":0.3119769025450869,"score_spread":0.2739060611480917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}