{"id":"W2066118621","doi":"10.1016/j.vaccine.2004.08.032","title":"Development of a recombinant Leishmania major strain sensitive to ganciclovir and 5-fluorocytosine for use as a live vaccine challenge in clinical trials","year":2004,"lang":"en","type":"article","venue":"Vaccine","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Vancouver Coastal Health Research Institute; Vancouver Coastal Health","funders":"F. Hoffmann-La Roche","keywords":"Ganciclovir; Thymidine kinase; Biology; Virology; Leishmaniasis; Leishmania; Thymidine; Drug; In vivo; In vitro; Microbiology; Pharmacology; Immunology; Human cytomegalovirus; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001252347,0.0008975732,0.0007522101,0.0005859567,0.0003505736,0.0006155352,0.0008514228,0.001030393,0.001604867],"category_scores_gemma":[0.0005302337,0.000439917,0.0006714122,0.0002633571,0.000488119,0.0005295774,0.0002834141,0.001813033,0.000494096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004893965,"about_ca_system_score_gemma":0.0006358642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002056773,"about_ca_topic_score_gemma":0.002086571,"domain_scores_codex":[0.9994506,0.0001893936,0.00004752102,0.000093164,0.00009026432,0.0001289517],"domain_scores_gemma":[0.9997147,0.00007693037,0.00004890649,0.00005839653,0.00004716304,0.00005388439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001163407,0.0007696055,0.0001883934,0.00009610097,0.0000343318,0.00005491074,0.00004494233,0.0004819544,0.9927987,0.0002931508,0.0001424814,0.003932118],"study_design_scores_gemma":[0.002344858,0.02631264,0.002360135,0.00002609911,0.000159515,0.0005333318,0.00004874477,0.001851366,0.9617168,0.0001285765,0.004493321,0.00002451551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748417,0.001716147,0.01773744,0.0003552616,0.0001944229,0.001778791,0.001233806,0.0002210232,0.001921538],"genre_scores_gemma":[0.9779173,0.001030018,0.01623035,0.0001154157,0.00003725138,0.0005810019,0.002125267,0.00004013042,0.001923149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002056773,"threshold_uncertainty_score":0.006623149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1416890752131882,"score_gpt":0.4184353296092561,"score_spread":0.2767462543960679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}