{"id":"W2066136001","doi":"10.1158/1538-7445.am2011-4226","title":"Abstract 4226: Curcumin induced CaSR stimulates calpain autolysis in colon cancer","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Calpain; Chemistry; Calcium-sensing receptor; Curcumin; Calcium metabolism; Colorectal cancer; Receptor; Calcium; Blot; Endocrinology; Cancer; Internal medicine; Cancer research; Molecular biology; Enzyme; Biochemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007500719,0.000125832,0.0001382709,0.0001867191,0.000113063,0.00002277786,0.0001736239,0.0002358152,0.001499977],"category_scores_gemma":[0.00009882689,0.0001162425,0.0000630002,0.000376486,0.0001176094,0.000007495782,0.00007236092,0.0003007544,0.00002612883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001436762,"about_ca_system_score_gemma":0.0003225633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006283647,"about_ca_topic_score_gemma":0.003367108,"domain_scores_codex":[0.9985235,0.0001631885,0.0002128322,0.0004078545,0.000282704,0.0004099472],"domain_scores_gemma":[0.9993052,0.00002618939,0.00004784353,0.0002886138,0.0002041139,0.0001280507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003370406,0.00009173187,0.009762842,0.00004125729,0.00004076824,0.00001238712,0.0002792097,0.0001921581,0.9698336,0.00003859429,0.003065991,0.01630444],"study_design_scores_gemma":[0.001005562,0.0002007267,0.08979043,0.00009105313,0.00001000631,0.000002513304,0.0001810178,0.0004465632,0.8852106,0.0001855914,0.02259853,0.000277366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968822,0.001183143,0.00006208488,0.000264562,0.0001831496,0.0004000816,0.00001791329,0.00001499144,0.0009918462],"genre_scores_gemma":[0.9968146,0.0003130985,0.00003131162,0.00008479743,0.0002408854,0.0003765498,0.00003570093,0.00002519154,0.002077866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08462294,"threshold_uncertainty_score":0.9994128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.120305919071779,"score_gpt":0.4051298831994957,"score_spread":0.2848239641277167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}