{"id":"W2066199795","doi":"10.1038/ng.1053","title":"Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes","year":2012,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":361,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University and Génome Québec Innovation Centre; McGill University; Centre Hospitalier de l’Université de Montréal; PROCURE","funders":"Agence Nationale de la Recherche; Wellcome Trust","keywords":"Minor allele frequency; Biology; Type 2 diabetes; Odds ratio; Nonsynonymous substitution; Genome-wide association study; Genetics; Genotyping; Allele; Internal medicine; Single-nucleotide polymorphism; Allele frequency; Endocrinology; Genotype; Diabetes mellitus; Gene; Medicine; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005317574,0.001959582,0.0009059224,0.001097482,0.001203449,0.0008737419,0.0009870261,0.002533965,0.007180755],"category_scores_gemma":[0.002222262,0.0005498976,0.0009352151,0.0009445156,0.0009413864,0.0004213072,0.0007095514,0.001632374,0.0006699517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003677731,"about_ca_system_score_gemma":0.000286037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001978177,"about_ca_topic_score_gemma":0.001882307,"domain_scores_codex":[0.9991795,0.0001715028,0.0001443004,0.000268191,0.0001497987,0.0000866962],"domain_scores_gemma":[0.9983687,0.0004596408,0.0007523253,0.0001177709,0.00008527405,0.0002164136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01020599,0.0006977492,0.1322606,0.0005059579,0.002260329,0.1369651,0.001393218,0.00215994,0.6704353,0.007174366,0.004452992,0.0314884],"study_design_scores_gemma":[0.001849858,0.001503454,0.5498035,0.0005243897,0.003784996,0.3502296,0.001064443,0.00779438,0.05328028,0.01174756,0.01808045,0.0003370107],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988283,0.001659898,0.004805025,0.001137468,0.0003396161,0.00004272848,0.0007126427,0.0001945292,0.002825147],"genre_scores_gemma":[0.9951555,0.0004052942,0.002400601,0.0003237861,0.0002603698,0.00002092502,0.0002494327,0.0001164317,0.001067651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007180755,"threshold_uncertainty_score":0.02402198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351403142425241,"score_gpt":0.2504941451937269,"score_spread":0.2369801137694745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}