{"id":"W2066237466","doi":"10.1128/jvi.76.14.7343-7348.2002","title":"PG13 Packaging Cells Produce Recombinant Retroviruses Carrying a Diphtheria Toxin Mutant Which Kills Cancer Cells","year":2002,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec; Centre hospitalier universitaire de Québec","funders":"","keywords":"Diphtheria toxin; Biology; Recombinant DNA; Suicide gene; Cell culture; Virology; Mutant; Virus; Recombinant virus; Transfection; Genetic enhancement; Cancer cell; Retrovirus; Immunotoxin; Toxin; Gene; Molecular biology; Microbiology; In vitro; Cancer; Cytotoxicity; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002968736,0.000504917,0.0003242061,0.0002876052,0.0001776425,0.0003848877,0.0004037645,0.0004384362,0.001876156],"category_scores_gemma":[0.0002747152,0.0002215678,0.0002805491,0.0003721165,0.0002488645,0.0002079914,0.0002539118,0.0006905135,0.001981436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002330721,"about_ca_system_score_gemma":0.0001702303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003037714,"about_ca_topic_score_gemma":0.0003569249,"domain_scores_codex":[0.9998503,0.00002851826,0.00002079756,0.00002534126,0.00005312524,0.00002197536],"domain_scores_gemma":[0.9998038,0.00005610316,0.00005092326,0.00004497255,0.00002092427,0.00002327194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007160414,0.0000400505,0.0004317391,0.0000666562,0.000006359061,0.00009850773,0.00003865514,0.00009635234,0.9928433,0.0009641623,0.0003515084,0.004991065],"study_design_scores_gemma":[0.00002653829,0.0003507518,0.002130001,0.00001322946,0.00003085064,0.0008407233,0.00002206024,0.001002502,0.9782916,0.0003189349,0.016965,0.000007664791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8128431,0.002299094,0.1530134,0.000345731,0.0002776465,0.0009489923,0.006305681,0.002042862,0.02192358],"genre_scores_gemma":[0.8303711,0.002537847,0.1216248,0.0002198644,0.00006234174,0.0003962824,0.02005265,0.0004693406,0.02426567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001876156,"threshold_uncertainty_score":0.006276309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02234628168441891,"score_gpt":0.2886408217949543,"score_spread":0.2662945401105354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}