{"id":"W2066250353","doi":"10.3389/fgene.2015.00161","title":"Transcriptional control of stem cell fate by E2Fs and pocket proteins","year":2015,"lang":"en","type":"review","venue":"Frontiers in Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"Biology; Cell fate determination; Embryonic stem cell; Stem cell; Epigenetics; E2F; Induced pluripotent stem cell; Transcription factor; Cell biology; Cellular differentiation; Genetics; Regeneration (biology); Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003338469,0.0003292477,0.0008621034,0.0001140251,0.00002447734,0.00001694916,0.000226297,0.0005432795,0.000003255359],"category_scores_gemma":[0.000006904092,0.0003169247,0.0001666744,0.0001094854,0.0001108197,0.000001910144,0.00004843239,0.0001699282,9.803734e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003305974,"about_ca_system_score_gemma":0.0002347036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003794382,"about_ca_topic_score_gemma":0.000002685966,"domain_scores_codex":[0.9982963,0.0002107675,0.0005937617,0.000439886,0.0002123817,0.0002469298],"domain_scores_gemma":[0.9991469,0.000008794498,0.0002983092,0.0003304562,0.00009856118,0.000117009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003459964,0.0001081773,0.0003852153,0.003301207,0.0001344081,0.000001710524,0.00004949239,0.00004167444,0.006423318,0.000007654472,0.002888146,0.9866244],"study_design_scores_gemma":[0.0007146922,0.0002774795,0.000009330362,0.0002951802,0.0002116182,0.000001499101,0.00002271418,0.00005867504,0.003872697,0.00008128338,0.9941326,0.0003222703],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006846696,0.9748413,0.02248121,0.000006065812,0.0003439051,0.000879749,0.0005756138,0.000003726846,0.0001837812],"genre_scores_gemma":[0.0009066996,0.9937904,0.004087766,0.0000156562,0.0001026711,0.00007216567,0.0004824386,0.00005585227,0.0004863886],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9912444,"threshold_uncertainty_score":0.9999283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01905076114976002,"score_gpt":0.2648654350698481,"score_spread":0.245814673920088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}