{"id":"W2066254965","doi":"10.1038/nature09460","title":"The patterns and dynamics of genomic instability in metastatic pancreatic cancer","year":2010,"lang":"en","type":"article","venue":"Nature","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":1324,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"National Cancer Institute; Wellcome Trust; National Institutes of Health; Uehara Memorial Foundation; Skip Viragh Foundation","keywords":"Pancreatic cancer; Genome instability; Metastasis; Cancer; Somatic evolution in cancer; Exome sequencing; Biology; Carcinogenesis; Exome; Evolutionary dynamics; Genetic heterogeneity; Genome; Cancer research; Oncology; Medicine; Genetics; Mutation; Gene; DNA; Phenotype; Population","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003031083,0.00007606576,0.0002071323,0.001794577,0.0002571638,0.0007268182,0.0002353282,0.0002365807,0.002262862],"category_scores_gemma":[0.001831269,0.0001559318,0.0001240973,0.001174152,0.0002694067,0.0006272021,0.0003290924,0.0003088029,0.0003331161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000287851,"about_ca_system_score_gemma":0.000154942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00129715,"about_ca_topic_score_gemma":0.00179659,"domain_scores_codex":[0.9998028,0.00003576375,0.00001993968,0.00004568498,0.00005581125,0.00004010724],"domain_scores_gemma":[0.9992732,0.0002162173,0.0002489486,0.00005921547,0.0001293794,0.0000729468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002592887,0.00006573289,0.7200878,0.0001284555,0.0001743677,0.0006666594,0.0007723535,0.001670241,0.2004624,0.001970797,0.001064529,0.07034383],"study_design_scores_gemma":[0.000008859531,0.0001432371,0.9839261,0.000009983531,0.00003131671,0.001567078,0.0004676871,0.001335215,0.009093729,0.001051555,0.002354297,0.00001109323],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943942,0.00220598,0.0006870689,0.0001485713,0.000005093713,0.000006536017,0.000501945,0.000027842,0.002022777],"genre_scores_gemma":[0.9984054,0.0006078364,0.0001696292,0.00001872948,0.00001334526,0.000006853779,0.0001908808,0.000007589163,0.0005796902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002262862,"threshold_uncertainty_score":0.007570028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01452769535676719,"score_gpt":0.3488258455886692,"score_spread":0.3342981502319021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}