{"id":"W2066268568","doi":"10.1038/509s13a","title":"Perspective: Synthetic biology revives antibiotics","year":2014,"lang":"en","type":"article","venue":"Nature","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Perspective (graphical); Synthetic biology; Antibiotics; Biology; Computational biology; Computer science; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001713683,0.0001179703,0.0002353937,0.00006800266,0.00005527156,0.00001024919,0.00008988234,0.0008801407,0.0001882994],"category_scores_gemma":[0.001228936,0.00007548229,0.00008288951,0.0001522324,0.00009322327,0.00002332008,0.00003075984,0.001291688,0.00007400687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003991867,"about_ca_system_score_gemma":0.00002194062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009199415,"about_ca_topic_score_gemma":0.000002054467,"domain_scores_codex":[0.9992926,0.00004871424,0.0001023685,0.0002983062,0.00007782414,0.0001802637],"domain_scores_gemma":[0.9993809,0.00006044877,0.0000419216,0.0002830397,0.000170397,0.00006323029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001249579,0.0001329615,0.001478576,0.0001473185,0.00008522369,0.000009725343,0.000105091,1.681347e-7,0.8927038,0.06086452,0.0250191,0.01932861],"study_design_scores_gemma":[0.0005655791,0.0003439955,0.006877397,0.0002292656,0.0001688599,0.0001510621,0.0001054541,0.00003947804,0.4012501,0.002390363,0.5876001,0.0002783387],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8036821,0.01826149,0.0000933108,0.1107644,0.001751897,0.000749412,0.00003902983,0.0003149329,0.06434336],"genre_scores_gemma":[0.9927771,0.0002145494,0.001349021,0.00305372,0.0006554887,2.929632e-8,0.000008353331,0.000013465,0.001928263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.562581,"threshold_uncertainty_score":0.6788451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007183067686331773,"score_gpt":0.2816795402383536,"score_spread":0.2744964725520219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}