{"id":"W2066268568","doi":"10.1038/509s13a","title":"Perspective: Synthetic biology revives antibiotics","year":2014,"lang":"en","type":"article","venue":"Nature","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Perspective (graphical); Synthetic biology; Antibiotics; Biology; Computational biology; Computer science; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00256161,0.001404786,0.0009145234,0.001017413,0.001180783,0.003306045,0.001320172,0.009512314,0.01984052],"category_scores_gemma":[0.002145241,0.0003646793,0.0005647789,0.0007777179,0.005224875,0.007693317,0.002425431,0.009361508,0.007627635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001948966,"about_ca_system_score_gemma":0.002875441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004520141,"about_ca_topic_score_gemma":0.001216194,"domain_scores_codex":[0.9988744,0.0003012168,0.00005180525,0.0001458126,0.0004803466,0.0001464767],"domain_scores_gemma":[0.9975599,0.001136538,0.0002148774,0.0001584452,0.0004802519,0.0004500698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003342645,0.0001752162,0.0001677369,0.002375414,0.00005965419,0.0006350774,0.0002062473,0.0006707402,0.01173483,0.3779659,0.4619869,0.143688],"study_design_scores_gemma":[0.00005607926,0.000118869,0.0000762368,0.0002240291,0.00001611186,0.0003428336,0.0001805328,0.0001626799,0.001388889,0.1110992,0.8863198,0.00001467038],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.00161328,0.3608245,0.007932574,0.5013674,0.07720292,0.00003815136,0.0002371466,0.0002520301,0.05053201],"genre_scores_gemma":[0.05229134,0.4743342,0.008461107,0.2787648,0.1395918,0.00008714144,0.0002085794,0.0001260891,0.04613497],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01984052,"threshold_uncertainty_score":0.06637311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007183067686331773,"score_gpt":0.2816795402383536,"score_spread":0.2744964725520219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}