{"id":"W2066295524","doi":"10.1021/bi401606f","title":"Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage","year":2014,"lang":"en","type":"article","venue":"Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Medical Research Council; Parkinson's UK; Wellcome Trust","keywords":"Clusterin; Chemistry; Oligomer; Intracellular; Neurotoxicity; Biophysics; Extracellular; Long-term potentiation; Calcium in biology; Cell biology; Microglia; Biochemistry; Astrocyte; Amyloid (mycology); Hippocampal formation; NADPH oxidase; Reactive oxygen species; Biology; Apoptosis; Inflammation; Neuroscience; Receptor; Toxicity; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001427975,0.0004247032,0.0004000526,0.0001946234,0.000230188,0.0003298237,0.0001607049,0.0004229824,0.000782398],"category_scores_gemma":[0.0001243725,0.0001854516,0.0003566896,0.0001519477,0.0002070831,0.0003136188,0.0003400374,0.0004901958,0.0003527095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002422402,"about_ca_system_score_gemma":0.000183587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005502664,"about_ca_topic_score_gemma":0.001039615,"domain_scores_codex":[0.9997981,0.00002736081,0.00001564695,0.00004184022,0.00007946182,0.00003755906],"domain_scores_gemma":[0.9998952,0.00001661486,0.00002342325,0.0000216678,0.00001975991,0.00002324459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006297461,0.00001866482,0.0004528877,0.00006307149,0.00001057205,0.0001814927,0.0000401225,0.00009283321,0.9970062,0.0002136144,0.00004159169,0.001815886],"study_design_scores_gemma":[0.00002065422,0.0005216454,0.01241265,0.00001839652,0.0000325089,0.0009628694,0.0001087848,0.001407216,0.9813152,0.0005090449,0.002682367,0.000008667861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849901,0.002958668,0.007353394,0.0001680164,0.00006135101,0.00008481974,0.0001879179,0.000150637,0.004045194],"genre_scores_gemma":[0.9895718,0.001910727,0.006033036,0.0001348297,0.00002452339,0.00008116166,0.0001034991,0.00001687852,0.002123582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000782398,"threshold_uncertainty_score":0.002617419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02614787129582657,"score_gpt":0.3024927272717934,"score_spread":0.2763448559759669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}