{"id":"W2066295524","doi":"10.1021/bi401606f","title":"Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage","year":2014,"lang":"en","type":"article","venue":"Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Medical Research Council; Parkinson's UK; Wellcome Trust","keywords":"Clusterin; Chemistry; Oligomer; Intracellular; Neurotoxicity; Biophysics; Extracellular; Long-term potentiation; Calcium in biology; Cell biology; Microglia; Biochemistry; Astrocyte; Amyloid (mycology); Hippocampal formation; NADPH oxidase; Reactive oxygen species; Biology; Apoptosis; Inflammation; Neuroscience; Receptor; Toxicity; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007402625,0.0001940551,0.0001867097,0.00006410223,0.00007650861,0.00003470588,0.0001479161,0.0000799572,0.0003094723],"category_scores_gemma":[0.0001546177,0.0001674135,0.00009515419,0.0001279577,0.00006567634,0.00003342135,0.00008859083,0.0001856551,0.0004132671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005748981,"about_ca_system_score_gemma":0.0001657306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007910917,"about_ca_topic_score_gemma":3.905936e-7,"domain_scores_codex":[0.9986129,0.00002760828,0.0001326138,0.000349556,0.0004837333,0.000393623],"domain_scores_gemma":[0.9987806,0.00005994067,0.00003520733,0.000363844,0.00005408495,0.0007063134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01008518,0.007045885,0.454892,0.001268799,0.0211049,0.002387832,0.0005777846,0.0000353841,0.3562672,0.0002343556,0.09585445,0.05024619],"study_design_scores_gemma":[0.002598602,0.0008700175,0.15452,0.0001514751,0.0003014282,0.00002467026,0.00005187774,0.00001907074,0.8399304,0.0000165733,0.001269453,0.0002464704],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896526,0.0001601461,0.000006916162,0.0002997971,0.0000360437,0.0001753766,0.0001356809,0.00006644517,0.009466938],"genre_scores_gemma":[0.9979626,0.00001005147,0.0001680054,0.0009268637,0.0002844263,0.0000340063,0.0004004568,0.00002704074,0.0001865292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4836631,"threshold_uncertainty_score":0.6826925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02614787129582657,"score_gpt":0.3024927272717934,"score_spread":0.2763448559759669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}