{"id":"W2066302732","doi":"10.1371/journal.pntd.0001736","title":"Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51","year":2012,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"King's University College; Western University","funders":"Fundação Oswaldo Cruz; National Institute of Allergy and Infectious Diseases; Conselho Nacional de Desenvolvimento Científico e Tecnológico; National Institutes of Health; Sandler Foundation","keywords":"Chagas disease; Trypanosoma cruzi; Benznidazole; Biology; Posaconazole; Pharmacology; Drug discovery; Population; Drug repositioning; Neglected tropical diseases; Drug; Virology; Disease; Microbiology; Amphotericin B; Medicine; Antifungal; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001754887,0.000644086,0.0004902637,0.0005607252,0.0002081149,0.0003443336,0.0003388081,0.0002746756,0.003709698],"category_scores_gemma":[0.0001936294,0.0001366171,0.000388502,0.0004752854,0.0002307924,0.0002274069,0.0002914742,0.0006227577,0.001014135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003608502,"about_ca_system_score_gemma":0.000297527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008222903,"about_ca_topic_score_gemma":0.002492341,"domain_scores_codex":[0.9998912,0.00001321248,0.00001129473,0.00002857652,0.00002793857,0.00002780407],"domain_scores_gemma":[0.9999212,0.00001588391,0.00001661222,0.000007897072,0.00001896698,0.00001950917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001071535,0.0003180074,0.001445934,0.0006853294,0.0000659957,0.0005921623,0.0000618877,0.002173559,0.9573463,0.0005004554,0.001825238,0.03391374],"study_design_scores_gemma":[0.001085375,0.0137614,0.01317396,0.0001900798,0.0004579864,0.002811468,0.0001293658,0.004908876,0.922475,0.0004516004,0.04045549,0.00009925349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9386677,0.02682068,0.009800351,0.000729211,0.0003570223,0.0007816029,0.003881448,0.0006232016,0.01833882],"genre_scores_gemma":[0.9585182,0.01737591,0.009250505,0.0008619516,0.00009555881,0.0004346423,0.003675553,0.00006470497,0.009723098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003709698,"threshold_uncertainty_score":0.01241022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02595923241509611,"score_gpt":0.2836109191296622,"score_spread":0.2576516867145661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}