{"id":"W2066310197","doi":"10.1210/me.2008-0190","title":"Transcriptional Regulation of the Human Growth Hormone Receptor (hGHR) Gene V2 Promoter by Transcriptional Activators and Repressor","year":2008,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Montreal Children's Hospital","funders":"Canadian Institutes of Health Research; Nagoya City University; McGill University Health Centre; McGill University","keywords":"Biology; Ccaat-enhancer-binding proteins; Molecular biology; Promoter; Transcription factor; Enhancer; ETS1; Exon; Transcriptional regulation; Chromatin immunoprecipitation; YY1; Repressor; Gene; Cell biology; Gene expression; Genetics; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006944434,0.0002593422,0.0004040046,0.0001468635,0.0002067355,0.00000628755,0.0001600115,0.0001878426,0.00009312554],"category_scores_gemma":[0.00005048792,0.000206189,0.0002076139,0.000224362,0.0005204771,0.0001230583,0.00004106582,0.0003490158,0.000006208948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005385626,"about_ca_system_score_gemma":0.0000693643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006591641,"about_ca_topic_score_gemma":6.878867e-7,"domain_scores_codex":[0.9980977,0.0001370293,0.0004848873,0.0004664847,0.0004209651,0.0003929576],"domain_scores_gemma":[0.9991679,0.00002159243,0.0001450951,0.000378077,0.0001594398,0.0001279402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001922477,0.0002235511,0.01231627,0.00003331486,0.0001494826,0.00002307979,0.000273295,0.000001029672,0.9795757,0.004817151,0.002256129,0.0001387665],"study_design_scores_gemma":[0.001958875,0.0003377665,0.3411861,0.00001443052,0.00008826677,0.0004200152,0.00001672958,0.000009080882,0.6522057,0.0003384562,0.003270381,0.0001541649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939818,0.00155294,0.0006840163,0.002327133,0.0001337568,0.0005340032,0.00005739999,0.00005621121,0.0006727614],"genre_scores_gemma":[0.9979188,0.0002355463,0.0005332715,0.000432038,0.00006807441,0.00005022531,0.0001613958,0.00004088871,0.0005597065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3288699,"threshold_uncertainty_score":0.8408142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01458009532667316,"score_gpt":0.226001625958983,"score_spread":0.2114215306323098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}