{"id":"W2066310197","doi":"10.1210/me.2008-0190","title":"Transcriptional Regulation of the Human Growth Hormone Receptor (hGHR) Gene V2 Promoter by Transcriptional Activators and Repressor","year":2008,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Montreal Children's Hospital","funders":"Canadian Institutes of Health Research; Nagoya City University; McGill University Health Centre; McGill University","keywords":"Biology; Ccaat-enhancer-binding proteins; Molecular biology; Promoter; Transcription factor; Enhancer; ETS1; Exon; Transcriptional regulation; Chromatin immunoprecipitation; YY1; Repressor; Gene; Cell biology; Gene expression; Genetics; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001847828,0.0003547774,0.0001559862,0.0001601188,0.0001153656,0.0003245054,0.0001336204,0.000163227,0.0006623596],"category_scores_gemma":[0.0001512571,0.0001736392,0.0002776432,0.0001027872,0.000237716,0.0001347512,0.0002788648,0.0002673821,0.0003091484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002776903,"about_ca_system_score_gemma":0.0002416626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008763829,"about_ca_topic_score_gemma":0.001043617,"domain_scores_codex":[0.9997455,0.00005377393,0.00001313273,0.00009135903,0.00005215344,0.00004402512],"domain_scores_gemma":[0.9999328,0.00001849324,0.00001418318,0.000008952919,0.00001134787,0.0000142394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001089339,0.00001340507,0.0004266705,0.00002123335,0.000004225928,0.00004248365,0.00002593986,0.00006372522,0.9980866,0.0001907009,0.00003768756,0.0009783341],"study_design_scores_gemma":[0.00004015159,0.0002290647,0.008351536,0.00001457335,0.00001515268,0.0003707688,0.00007463926,0.002916301,0.9835938,0.000127921,0.004256835,0.00000936559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792674,0.002293579,0.01543077,0.0001202497,0.00004940075,0.00005055601,0.0004629356,0.0001220133,0.002203054],"genre_scores_gemma":[0.9854837,0.0007385398,0.008285425,0.00009650014,0.0000208546,0.00005676344,0.0009726011,0.00003809369,0.004307479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008763829,"threshold_uncertainty_score":0.002215803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01458009532667316,"score_gpt":0.226001625958983,"score_spread":0.2114215306323098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}