{"id":"W2066315689","doi":"10.1097/qad.0000000000000199","title":"Resistance mutations against dolutegravir in HIV integrase impair the emergence of resistance against reverse transcriptase inhibitors","year":2014,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; U.S. Food and Drug Administration","keywords":"Dolutegravir; Virology; Integrase; Reverse transcriptase; Nevirapine; Integrase inhibitor; Lamivudine; Resistance mutation; Drug resistance; Regimen; Medicine; Biology; Virus; Human immunodeficiency virus (HIV); Genetics; Viral load; Internal medicine; Antiretroviral therapy; Polymerase chain reaction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005979061,0.0002505,0.0003889173,0.0002147302,0.0001255875,0.00001108906,0.0001847479,0.000085491,0.00005122052],"category_scores_gemma":[0.0002783114,0.0001741072,0.0001717122,0.0008518905,0.0001801278,0.0001217404,0.00002183447,0.0002653391,0.00004591412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00010344,"about_ca_system_score_gemma":0.0001611992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003419522,"about_ca_topic_score_gemma":0.0005997663,"domain_scores_codex":[0.9981532,0.0001670903,0.0006251259,0.000354142,0.0003715486,0.0003289563],"domain_scores_gemma":[0.9989012,0.0001505462,0.0001464313,0.0005444867,0.0001223352,0.0001349908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002853726,0.003283539,0.3185761,0.001429387,0.001066614,0.0008169597,0.04379122,0.0001921136,0.05526344,0.02564546,0.5088719,0.03820956],"study_design_scores_gemma":[0.02282116,0.0006396996,0.08991431,0.007614572,0.001192729,0.00001416803,0.03453818,0.0007736853,0.08025917,0.00519216,0.7547528,0.002287386],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9588749,0.001205365,0.0006702807,0.009127255,0.0003180372,0.0009025591,0.00007852661,0.00009194415,0.02873112],"genre_scores_gemma":[0.9732222,0.0002428242,0.004649988,0.0004804337,0.00006172666,0.00009123635,0.0001254931,0.00002799333,0.0210981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.245881,"threshold_uncertainty_score":0.7099886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009225039585877502,"score_gpt":0.2422023019927786,"score_spread":0.2329772624069011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}