{"id":"W2066334259","doi":"10.1016/j.bbmt.2007.09.014","title":"A Roadmap to Safe, Efficient, and Stable Lentivirus-Mediated Gene Therapy with Hematopoietic Cell Transplantation","year":2007,"lang":"en","type":"review","venue":"Biology of Blood and Marrow Transplantation","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Toronto General Hospital; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Genetic enhancement; Lentivirus; Viral vector; Transgene; Transplantation; Vector (molecular biology); Medicine; Haematopoiesis; Stem cell; Hematopoietic stem cell transplantation; Gene transfer; Genetically modified organism; Computational biology; Gene; Hematopoietic stem cell; Clinical trial; Cancer research; Bioinformatics; Human immunodeficiency virus (HIV); Virology; Biology; Genetics; Viral disease; Internal medicine; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001532118,0.001359258,0.001955251,0.001482168,0.0004103737,0.001667077,0.001734438,0.001861216,0.003263119],"category_scores_gemma":[0.0008245356,0.00039804,0.0005225552,0.001284502,0.001065082,0.002107208,0.0007767447,0.004511167,0.002325643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001444607,"about_ca_system_score_gemma":0.001736993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00125467,"about_ca_topic_score_gemma":0.001849761,"domain_scores_codex":[0.9996868,0.00005765236,0.00003119966,0.00004141032,0.0001500135,0.00003287644],"domain_scores_gemma":[0.9996471,0.0001610155,0.00002776817,0.00001510024,0.0001078099,0.00004110845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000127029,0.0002169376,0.0001628025,0.007327802,0.00009102115,0.0003505056,0.0000685727,0.0009221902,0.01268571,0.0338777,0.05404359,0.8901261],"study_design_scores_gemma":[0.00006540417,0.0001187254,0.0002966344,0.001013766,0.00005752067,0.0008216006,0.00003889509,0.0003508821,0.003781795,0.007383459,0.9860455,0.00002564911],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002356952,0.9925359,0.003040378,0.001064799,0.0007910435,0.00001739177,0.00002717611,0.00004130786,0.002246346],"genre_scores_gemma":[0.001329713,0.9938585,0.002385656,0.0005846923,0.0003213517,0.00002650032,0.00005473245,0.000007242844,0.001431588],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003263119,"threshold_uncertainty_score":0.01091623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02416227954549512,"score_gpt":0.3017304829416672,"score_spread":0.2775682033961721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}