{"id":"W2066334259","doi":"10.1016/j.bbmt.2007.09.014","title":"A Roadmap to Safe, Efficient, and Stable Lentivirus-Mediated Gene Therapy with Hematopoietic Cell Transplantation","year":2007,"lang":"en","type":"review","venue":"Biology of Blood and Marrow Transplantation","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Toronto General Hospital; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Genetic enhancement; Lentivirus; Viral vector; Transgene; Transplantation; Vector (molecular biology); Medicine; Haematopoiesis; Stem cell; Hematopoietic stem cell transplantation; Gene transfer; Genetically modified organism; Computational biology; Gene; Hematopoietic stem cell; Clinical trial; Cancer research; Bioinformatics; Human immunodeficiency virus (HIV); Virology; Biology; Genetics; Viral disease; Internal medicine; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004188169,0.0003987304,0.0007147823,0.0002654091,0.0000868129,0.00001610481,0.0001558052,0.0004424812,0.00001346657],"category_scores_gemma":[0.00000433623,0.0003158289,0.0001059352,0.0002171584,0.0001859778,0.000004983843,0.00001395308,0.0001585765,0.000003866022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000061785,"about_ca_system_score_gemma":0.0001601471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000297147,"about_ca_topic_score_gemma":0.0001359233,"domain_scores_codex":[0.9981661,0.0002382818,0.0004509451,0.0006276398,0.0001477653,0.0003692552],"domain_scores_gemma":[0.9992648,0.00008541286,0.0001957801,0.0002337689,0.00007834802,0.0001418592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005751248,0.0003652491,0.0002329559,0.01140061,0.0006399698,0.00003950626,0.0005127917,0.00001479921,0.7796652,0.00001627246,0.00001806626,0.2013433],"study_design_scores_gemma":[0.008440357,0.01526201,0.0001489997,0.002724647,0.002275153,0.0006684529,0.00006962568,0.000004539011,0.8728859,0.00001771388,0.09596475,0.001537884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2828024,0.7147586,0.0009411611,0.00001007326,0.0000373339,0.0008706638,0.0004775709,0.00001120011,0.00009094421],"genre_scores_gemma":[0.05942601,0.9375175,0.0004103353,0.00004805658,0.00005518444,0.00008241137,0.002349655,0.00004881061,0.00006203505],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2233764,"threshold_uncertainty_score":0.9999294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02416227954549512,"score_gpt":0.3017304829416672,"score_spread":0.2775682033961721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}