{"id":"W2066353338","doi":"10.4161/mabs.26844","title":"Antibody light chain variable domains and their biophysically improved versions for human immunotherapy","year":2013,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Ottawa; Health Canada; Agricultural Institute of Canada; National Research Council Canada","funders":"","keywords":"Panning (audio); Phage display; Immunoglobulin light chain; Computational biology; Protein engineering; Antibody; Chemistry; Antigen; Peptide library; Disulfide bond; Immunotherapy; Biophysics; Molecular biology; Biochemistry; Combinatorial chemistry; Peptide sequence; Biology; Peptide; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002630363,0.00019,0.0001420044,0.0001137714,0.00005410723,0.0002839497,0.0002088911,0.0002852578,0.0008544245],"category_scores_gemma":[0.0001842494,0.0000682235,0.0001584199,0.0001337609,0.0001471521,0.0001871999,0.0001665741,0.0004737906,0.0003031225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002165696,"about_ca_system_score_gemma":0.000107255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001358519,"about_ca_topic_score_gemma":0.0001561036,"domain_scores_codex":[0.9998996,0.00003159065,0.000005597868,0.00001769778,0.00002497613,0.00002045798],"domain_scores_gemma":[0.9999598,0.000006690265,0.00001109763,0.000006312349,0.000007453344,0.000008621247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001150425,0.00005282151,0.0003620489,0.00006411024,0.000008752687,0.00006439922,0.00001982292,0.0006505623,0.9872276,0.0008293653,0.0001698591,0.01043562],"study_design_scores_gemma":[0.00004815943,0.00133329,0.00295317,0.00002485348,0.00003659317,0.001181724,0.00003085038,0.00365769,0.9459875,0.0008294812,0.04390247,0.00001433868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9266111,0.02100789,0.04566292,0.0007461974,0.0001716791,0.00007610763,0.0003551116,0.0002167092,0.005152218],"genre_scores_gemma":[0.972436,0.004655988,0.01808199,0.000405953,0.00004599975,0.0000340587,0.000532588,0.00003901957,0.00376828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008544245,"threshold_uncertainty_score":0.002858341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190344383183693,"score_gpt":0.2945818068941203,"score_spread":0.2826783630622833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}