{"id":"W2066353338","doi":"10.4161/mabs.26844","title":"Antibody light chain variable domains and their biophysically improved versions for human immunotherapy","year":2013,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Ottawa; Health Canada; Agricultural Institute of Canada; National Research Council Canada","funders":"","keywords":"Panning (audio); Phage display; Immunoglobulin light chain; Computational biology; Protein engineering; Antibody; Chemistry; Antigen; Peptide library; Disulfide bond; Immunotherapy; Biophysics; Molecular biology; Biochemistry; Combinatorial chemistry; Peptide sequence; Biology; Peptide; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001166211,0.0001478122,0.0002521148,0.00007026413,0.0002723569,0.00004267368,0.0001000329,0.00007250605,0.0004114896],"category_scores_gemma":[0.00001583918,0.0000956975,0.00009502468,0.0001076623,0.00009151545,0.00006681548,0.00006432769,0.0001375874,0.00005551843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000200208,"about_ca_system_score_gemma":0.00003904941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005035934,"about_ca_topic_score_gemma":0.000005044643,"domain_scores_codex":[0.9991543,0.00002119923,0.0001559149,0.0002278431,0.0001096414,0.0003310427],"domain_scores_gemma":[0.9993754,0.0001025459,0.00003404545,0.0002197921,0.0001207274,0.000147501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001612391,0.0001393066,0.0004867753,0.00007608011,0.00009393811,0.000001887096,0.000178634,7.515555e-8,0.9885296,0.006127505,0.001215329,0.002989629],"study_design_scores_gemma":[0.01440629,0.006266039,0.1027484,0.0004143408,0.0001069263,0.0001013366,0.001108951,0.006949359,0.1717217,0.04170747,0.653304,0.001165205],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845668,0.0003827022,0.0012953,0.007926659,0.00008164749,0.0009872371,0.00004608996,0.00005078761,0.004662795],"genre_scores_gemma":[0.9818479,0.0001627077,0.002146632,0.00102692,0.000362013,0.0001186312,0.0001918708,0.00003405377,0.0141092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8168079,"threshold_uncertainty_score":0.4505523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190344383183693,"score_gpt":0.2945818068941203,"score_spread":0.2826783630622833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}