{"id":"W2066368611","doi":"10.1016/j.tips.2005.10.005","title":"Antidepressant action: to the nucleus and beyond","year":2005,"lang":"en","type":"review","venue":"Trends in Pharmacological Sciences","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":193,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"CREB; Antidepressant; Neurogenesis; Neuroscience; Monoamine neurotransmitter; Psychology; Depression (economics); Pharmacology; Medicine; Serotonin; Biology; Receptor; Transcription factor; Internal medicine; Hippocampus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007228657,0.0002668455,0.0005782743,0.0002566387,0.0004854887,0.0001639346,0.0009497995,0.0001192124,0.002247482],"category_scores_gemma":[0.0001017482,0.0001301395,0.0001389139,0.001723424,0.0005433822,0.0001522412,0.0003630542,0.0004807871,0.000135815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005155923,"about_ca_system_score_gemma":0.00003173217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006456955,"about_ca_topic_score_gemma":0.000009686183,"domain_scores_codex":[0.9975845,0.0004155172,0.0003646936,0.0007848442,0.000393175,0.0004572969],"domain_scores_gemma":[0.9990539,0.000540128,0.0001350408,0.0001131682,0.00000598733,0.0001518054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000002977134,0.00004222594,0.000004034234,0.00003322802,0.000002279302,0.00001571286,0.00003858287,0.0000192363,0.00009539127,0.0003777179,0.001886189,0.9974824],"study_design_scores_gemma":[0.0000722218,0.00009177152,0.00001907476,0.0001425391,0.00005027761,0.00004094477,0.00001595966,0.0001080608,0.00007653944,0.00003852713,0.9991425,0.000201608],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001151605,0.9777171,0.00000215699,0.001106608,0.0008771945,0.0003631528,0.00002535533,0.00007544454,0.01868138],"genre_scores_gemma":[0.004719235,0.9929262,0.0001244021,0.001230991,0.0003631497,0.00004728978,5.885281e-7,0.00001131941,0.0005768054],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9972808,"threshold_uncertainty_score":0.9986646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2777671040845792,"score_gpt":0.468962060633389,"score_spread":0.1911949565488098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}